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C. I. Edvard Smith
Researcher at Karolinska University Hospital
Publications - 229
Citations - 10846
C. I. Edvard Smith is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Bruton's tyrosine kinase & Oligonucleotide. The author has an hindex of 48, co-authored 225 publications receiving 9351 citations. Previous affiliations of C. I. Edvard Smith include Stockholm University & Gifu University.
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Journal ArticleDOI
Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting
Oscar P. B. Wiklander,Joel Z. Nordin,Aisling J. O’Loughlin,Ylva Gustafsson,Giulia Corso,Imre Mäger,Pieter Vader,Yi Lee,Helena Sork,Yiqi Seow,Nina Heldring,Lydia Alvarez-Erviti,C. I. Edvard Smith,Katarina Le Blanc,Paolo Macchiarini,Philipp Jungebluth,Matthew J.A. Wood,Samir El Andaloussi +17 more
TL;DR: This is the first extensive biodistribution investigation of EVs comparing the impact of several different variables, the results of which have implications for the design and feasibility of therapeutic studies using EVs.
Journal ArticleDOI
Cells release subpopulations of exosomes with distinct molecular and biological properties
Eduard Willms,Henrik J. Johansson,Imre Mäger,Imre Mäger,Yi Lee,K. Emelie M. Blomberg,Mariam Sadik,Amr Alaarg,C. I. Edvard Smith,Janne Lehtiö,Samir El Andaloussi,Samir El Andaloussi,Matthew J.A. Wood,Pieter Vader,Pieter Vader +14 more
TL;DR: It is demonstrated that cells release distinct exosome subpopulations with unique compositions that elicit differential effects on recipient cells that will advance the understanding of exosomal biology in health and disease and accelerate the development ofExosome-based diagnostics and therapeutics.
Journal ArticleDOI
Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties
Joel Z. Nordin,Yi Lee,Pieter Vader,Imre Mäger,Imre Mäger,Henrik J. Johansson,Wolf Heusermann,Oscar P. B. Wiklander,Mattias Hällbrink,Yiqi Seow,Jarred J. Bultema,Jonathan D. Gilthorpe,Tim Davies,Paul J. Fairchild,Susanne Gabrielsson,Nicole Meisner-Kober,Janne Lehtiö,C. I. Edvard Smith,Matthew J.A. Wood,Samir El Andaloussi,Samir El Andaloussi +20 more
TL;DR: A systematic comparison between two protocols for EV purification: ultrafiltration with subsequent liquid chromatography (UF-LC) and differential ultracentrifugation (UC) for EV recovery shows that UF-LC is scalable and adaptable for EV isolation from complex media types such as stem cell media, which is of huge significance for future clinical applications involving EVs.
Journal ArticleDOI
Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain.
Abdalla J. Mohamed,Liang Yu,Carl-Magnus Bäckesjö,Leonardo Vargas,Rani Faryal,Rani Faryal,Alar Aints,Alar Aints,Birger Christensson,Anna Berglöf,Mauno Vihinen,Beston F. Nore,C. I. Edvard Smith +12 more
TL;DR: Novel mutations in the pleckstrin homology domain investigated for their transforming capacity are described and it is shown that the mutant D43R behaves similar to E41K, already known to possess such activity.
Journal ArticleDOI
Interleukin 4 induces synthesis of IgE and IgG4 in human B cells.
Mats Lundgren,Ulla Persson,Ulla Persson,Per Larsson,Carl G.M. Magnusson,C. I. Edvard Smith,C. I. Edvard Smith,Lennart Hammarström,Lennart Hammarström,Eva Severinson +9 more
TL;DR: It is shown that IL 4 and phorbol 12‐myristate 13‐acetate (PMA) induce, on a per cell basis, very high IgE secretion in purified human B cells by using a mouse thymoma (EL4) co‐culture method.