J
Jae Sik Yu
Researcher at Sungkyunkwan University
Publications - 65
Citations - 884
Jae Sik Yu is an academic researcher from Sungkyunkwan University. The author has contributed to research in topics: Chemistry & Withania somnifera. The author has an hindex of 13, co-authored 60 publications receiving 493 citations. Previous affiliations of Jae Sik Yu include Kangwon National University.
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Journal ArticleDOI
Withaninsams A and B: Phenylpropanoid Esters from the Roots of Indian Ginseng (Withania somnifera)
Su Cheol Baek,Seoyoung Lee,Sil Kim,Mun Seok Jo,Jae Sik Yu,Yoon-Joo Ko,Young-Chang Cho,Ki Hyun Kim +7 more
TL;DR: This study is the first to report on phenylpropanoid esters with 4-methyl-1,4-pentanediol unit, and the anti-inflammatory mechanism through the inhibition of transcriptional iNOS protein expression was confirmed by western blotting experiments for the active compound 3, which showed decreased iNos protein expression.
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Lobatamunsolides A-C, Norlignans from the Roots of Pueraria lobata and their Nitric Oxide Inhibitory Activities in Macrophages.
TL;DR: Phytochemical investigation of the methanol (MeOH) extract of Pueraria lobata roots, known as “kudzu”, combined with liquid chromatography/mass spectrometry (LC/MS)-based analysis, resulted in the identification of four norlignans, including three new norlIGNans, lobatamunsolides A–C (1–3), and five known isoflavonoids (5–9).
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7α,15-Dihydroxydehydroabietic acid from Pinus koraiensis inhibits the promotion of angiogenesis through downregulation of VEGF, p-Akt and p-ERK in HUVECs
Tae Kyoung Lee,Jun Yeon Park,Jae Sik Yu,Tae Su Jang,Seong Taek Oh,Changhyun Pang,Yoon-Joo Ko,Ki Sung Kang,Ki-Hyun Kim +8 more
TL;DR: Experimental evidence of a novel biological activity of 7α,15-dihydroxydehydroabietic acid (5) as a potential antiangiogenic substance is provided and it is suggested that compound 5 could potentially be a useful adjuvant therapeutic substance for cancer prevention and treatment.
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Metabolite Profile of Cucurbitane-Type Triterpenoids of Bitter Melon (Fruit of Momordica charantia) and Their Inhibitory Activity against Protein Tyrosine Phosphatases Relevant to Insulin Resistance.
Yong Hoon Lee,Sunyoung Yoon,Jiyun Baek,Sung Jin Kim,Jae Sik Yu,Heesun Kang,Ki Sung Kang,Sang J. Chung,Ki Hyun Kim +8 more
TL;DR: In this paper, a qualitative analysis of cucurbitane-type triterpenoids of bitter melon (fruit of Momordica charantia L.) using ultraperformance liquid chromatography quadrupole time-of-flight mass spectrometry revealed 27 promising cucurbitsane type triterbenoids.
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Antioxidant and Anti-Inflammatory Effects of White Mulberry (Morus alba L.) Fruits on Lipopolysaccharide-Stimulated RAW 264.7 Macrophages.
TL;DR: In this article, the protection of white mulberry (Morus alba) fruits on lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages was investigated.