S
Stefanie Scheu
Researcher at University of Düsseldorf
Publications - 67
Citations - 4371
Stefanie Scheu is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: Immune system & Tumor necrosis factor alpha. The author has an hindex of 31, co-authored 64 publications receiving 3835 citations. Previous affiliations of Stefanie Scheu include University of California, San Francisco & Technische Universität München.
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Journal ArticleDOI
Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development
Babacar Cisse,Michele L. Caton,Manfred Lehner,Takahiro Maeda,Stefanie Scheu,Stefanie Scheu,Richard M. Locksley,Dan Holmberg,Christiane Zweier,Nicolette S. den Hollander,Sarina G. Kant,Wolfgang Holter,Anita Rauch,Yuan Zhuang,Boris Reizis +14 more
TL;DR: It is reported that basic helix-loop-helix transcription factor E2-2/Tcf4 is preferentially expressed in murine and human PDCs and revealed a key function of E proteins in the innate immune system.
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B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator.
John R. Sedy,Maya Gavrieli,Karen G. Potter,Michelle A. Hurchla,R. Coleman Lindsley,Kai Hildner,Stefanie Scheu,Klaus Pfeffer,Carl F. Ware,Theresa L. Murphy,Kenneth M. Murphy +10 more
TL;DR: The conservation of the BTLA-HVEM interaction between mouse and human suggests that this system is an important pathway regulating lymphocyte activation and/or homeostasis in the immune response.
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Thymic Medullary Epithelial Cell Differentiation, Thymocyte Emigration, and the Control of Autoimmunity Require Lympho–Epithelial Cross Talk via LTβR
TL;DR: It is shown that thymocytes and medullary epithelial cells (MECs) communicate via the lymphotoxin β receptor (LTβR) signaling axis, suggesting an unexpected role for LTβR signaling in central tolerance induction.
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Targeted Disruption of LIGHT Causes Defects in Costimulatory T Cell Activation and Reveals Cooperation with Lymphotoxin β in Mesenteric Lymph Node Genesis
TL;DR: In vivo evidence is provided for the first time for a cooperative role for LIGHT and LTβ in lymphoid organogenesis and indicates important costimulatory functions for LIGHTS in T cell activation.
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The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling
Taylor A. Doherty,Pejman Soroosh,Naseem Khorram,Satoshi Fukuyama,Peter Rosenthal,Jae Youn Cho,Paula S. Norris,Heonsik Choi,Stefanie Scheu,Klaus Pfeffer,Bruce L. Zuraw,Carl F. Ware,David H. Broide,Michael Croft +13 more
TL;DR: Pharmacological inhibition of LIGHT using a fusion protein between the IgG Fc domain and lymphotoxin β receptor reduces lung fibrosis, smooth muscle hyperplasia and airway hyperresponsiveness in mouse models of chronic asthma, despite having little effect on airway eosinophilia.