J
Jaime Imitola
Researcher at University of Connecticut
Publications - 101
Citations - 10178
Jaime Imitola is an academic researcher from University of Connecticut. The author has contributed to research in topics: Neural stem cell & Multiple sclerosis. The author has an hindex of 39, co-authored 94 publications receiving 9167 citations. Previous affiliations of Jaime Imitola include Ohio State University & Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
Chen Zhu,Ana C. Anderson,Anna Schubart,Huabao Xiong,Jaime Imitola,Samia J. Khoury,Xin Xiao Zheng,Terry B. Strom,Vijay K. Kuchroo +8 more
TL;DR: The data suggest that the Tim-3–galectin-9 pathway may have evolved to ensure effective termination of effector TH1 cells.
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Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1α/CXC chemokine receptor 4 pathway
Jaime Imitola,Khadir Raddassi,Kook In Park,Franz Josef Mueller,Franz Josef Mueller,Marta Nieto,Yang D. Teng,Dan Frenkel,Jianxue Li,Richard L. Sidman,Christopher A. Walsh,Evan Y. Snyder,Evan Y. Snyder,Samia J. Khoury +13 more
TL;DR: The data implicate SDF-1α/CXCR4, representative of the inflammatory milieu characterizing many pathologies, as a pathway that activates NSC molecular programs during injury and suggest that inflammation may be viewed not simply as playing an adverse role but also as providing stimuli that recruit cells with a regenerative homeostasis-promoting capacity.
Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1 alpha/CXC chemokine receptor 4 pathway
Yang D. Teng,Dan Frenkel,Marta Nieto,Franz-Josef Mueller,Kook In Park,Khadir Raddassi,Jaime Imitola,Jianxue Li,Richard L. Sidman,Christopher A. Walsh,Evan Y. Snyder,Samia J. Khoury +11 more
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Expression of Cux‐1 and Cux‐2 in the subventricular zone and upper layers II–IV of the cerebral cortex
Marta Nieto,Edwin S. Monuki,Hua Tang,Jaime Imitola,Nicole Haubst,Samia J. Khoury,James M. Cunningham,Magdalena Götz,Christopher A. Walsh +8 more
TL;DR: The existence of an intermediate neuronal precursor in the SVZ dedicated to the generation of upper layer neurons, marked specifically by Cux‐2 is supported, suggesting potential roles as determinants of the neuronal fate of the upper cortical layer neurons.
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Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis
Alan D. Salama,Tanuja Chitnis,Tanuja Chitnis,Jaime Imitola,Jaime Imitola,Mohammed Javeed I. Ansari,Hisaya Akiba,Fumihiko Tushima,Miyuki Azuma,Hideo Yagita,Mohamed H. Sayegh,Mohamed H. Sayegh,Samia J. Khoury +12 more
TL;DR: The programmed death-1 (PD-1) costimulatory pathway plays a critical role in regulating peripheral tolerance in murine EAE and appears to be a major contributor to the resistance of disease induction in CD28-deficient mice.