J
Jake A. Kloeber
Researcher at Mayo Clinic
Publications - 25
Citations - 504
Jake A. Kloeber is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Biology & Homologous recombination. The author has an hindex of 7, co-authored 18 publications receiving 246 citations. Previous affiliations of Jake A. Kloeber include Broad Institute & Harvard University.
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Journal ArticleDOI
Homologous recombination into the eosinophil peroxidase locus generates a strain of mice expressing Cre recombinase exclusively in eosinophils
Alfred D. Doyle,Elizabeth A. Jacobsen,Sergei I. Ochkur,Lian Willetts,Kelly Shim,Joseph Neely,Jake A. Kloeber,Will E. LeSuer,R.S. Pero,Paige Lacy,Redwan Moqbel,Nancy A. Lee,James J. Lee +12 more
TL;DR: The development of eoCRE mice represents a milestone in studies of eosinophil biology, permitting eos inophil‐specific gene targeting and overexpression in the mouse as part of next‐generation studies attempting to define eosInophil effector functions.
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Expression of the secondary granule proteins major basic protein 1 (MBP-1) and eosinophil peroxidase (EPX) is required for eosinophilopoiesis in mice
Alfred D. Doyle,Elizabeth A. Jacobsen,Sergei I. Ochkur,Michael P. McGarry,Kevin G. Shim,David T. C. Nguyen,Cheryl A. Protheroe,Dana Colbert,Jake A. Kloeber,Joseph Neely,Kelly P. Shim,Kimberly D. Dyer,Helene F. Rosenberg,James J. Lee,Nancy A. Lee +14 more
TL;DR: A knockout approach targeting the genes encoding these proteins demonstrated that, unlike in mice containing a single deficiency of only MBP-1 or EPX, the absence of both granule proteins resulted in the near complete loss of peripheral blood eosinophils with no apparent impact on any other hematopoietic lineage.
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DNA end resection and its role in DNA replication and DSB repair choice in mammalian cells.
TL;DR: The general process of DNA end resection is reviewed and its role in DNA replication and repair pathway choice, essential for error-free homologous recombination DNA repair, the degradation of incorrectly replicated DNA and double-strand break repair choice is reviewed.
Journal ArticleDOI
Eosinophil-derived IL-13 Promotes Emphysema
Alfred D. Doyle,Manali Mukherjee,William E. LeSuer,Tyler B. Bittner,Saif M. Pasha,Justin J. Frere,Joseph Neely,Jake A. Kloeber,Kelly P. Shim,Kelly P. Shim,Sergei I. Ochkur,Terence Ho,Sarah Svenningsen,Benjamin L. Wright,Benjamin L. Wright,Matthew A. Rank,James J. Lee,Parameswaran Nair,Elizabeth A. Jacobsen +18 more
TL;DR: An underappreciated mechanism by which eosinophils contribute to the pathologies associated with asthma and COPD is suggested.
Journal ArticleDOI
Genomic discovery and clonal tracking in multiple myeloma by cell-free DNA sequencing.
Guangwu Guo,Guangwu Guo,Noopur Raje,Charles Seifer,Charles Seifer,Jake A. Kloeber,Jake A. Kloeber,Randi Isenhart,Randi Isenhart,Gavin Ha,Gavin Ha,Andrew Yee,Elizabeth O'Donnell,Yu-Tzu Tai,Paul G. Richardson,Giada Bianchi,Jacob P. Laubach,Diane Warren,Erica Gemme,Jordan Voisine,Jordan Voisine,Julia Frede,Julia Frede,Antonis Kokkalis,Antonis Kokkalis,Huiyoung Yun,Huiyoung Yun,Valeriya Dimitrova,Valeriya Dimitrova,Tushara Vijaykumar,Tushara Vijaykumar,Matthew Meyerson,Nikhil C. Munshi,Kenneth C. Anderson,Birgit Knoechel,Birgit Knoechel,Jens G. Lohr +36 more
TL;DR: It is hypothesized that cfDNA can be used to track disease load and clonal evolution of MM, to provide longitudinal genetic information about disease evolution that is not accessible by bone marrow biopsy.