J
Jakob J. Metzger
Researcher at Rockefeller University
Publications - 29
Citations - 1396
Jakob J. Metzger is an academic researcher from Rockefeller University. The author has contributed to research in topics: Wnt signaling pathway & Gastrulation. The author has an hindex of 15, co-authored 28 publications receiving 937 citations. Previous affiliations of Jakob J. Metzger include Max Planck Society & University of Göttingen.
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Journal ArticleDOI
A Balance between Secreted Inhibitors and Edge Sensing Controls Gastruloid Self-Organization.
Fred Etoc,Jakob J. Metzger,Albert Ruzo,Christoph Kirst,Anna Yoney,M. Zeeshan Ozair,Ali H Brivanlou,Eric D. Siggia +7 more
TL;DR: A quantitative model is developed that integrates edge sensing and inhibitors to predict human fate positioning in gastruloids and, potentially, the human embryo.
Journal ArticleDOI
Non-equilibrium steady states of stochastic processes with intermittent resetting
Stephan Eule,Jakob J. Metzger +1 more
TL;DR: In this article, the authors obtain the general solution for the distribution of processes in which waiting times between reset events are drawn from an arbitrary distribution, which allows for the investigation of a broader class of much more realistic processes.
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Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning
Sophie M. Morgani,Sophie M. Morgani,Jakob J. Metzger,Jennifer Nichols,Eric D. Siggia,Anna-Katerina Hadjantonakis +5 more
TL;DR: The mouse micropattern system offers a robust scalable method to generate regionalized cell types present in vivo, resolve how signals promote distinct identities and generate patterns, and compare mechanisms operating in vivo and in vitro and across species.
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Self-organization of human embryonic stem cells on micropatterns
Alessia Deglincerti,Fred Etoc,M Cecilia Guerra,Iain Martyn,Jakob J. Metzger,Albert Ruzo,Mijo Simunovic,Anna Yoney,Ali H. Brivanlou,Eric D. Siggia,Aryeh Warmflash +10 more
TL;DR: A micropatterning approach in which human embryonic stem cells are confined to disk-shaped, submillimeter colonies, which describes a robust platform for quantitative analysis of the mechanisms associated with pattern formation at the onset of gastrulation.
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A 3D model of a human epiblast reveals BMP4-driven symmetry breaking.
Mijo Simunovic,Jakob J. Metzger,Fred Etoc,Anna Yoney,Albert Ruzo,Iain Martyn,Gist F. Croft,Dong Shin You,Ali H Brivanlou,Eric D. Siggia +9 more
TL;DR: It is shown that a model human epiblast can break axial symmetry despite the absence of asymmetry in the initial signal and of extra-embryonic tissues or maternal cues, and that anterior–posterior symmetry breaking can be induced by BMP4 and WNT signalling.