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Sophie M. Morgani
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 24
Citations - 1050
Sophie M. Morgani is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Embryonic stem cell & Epiblast. The author has an hindex of 11, co-authored 20 publications receiving 720 citations. Previous affiliations of Sophie M. Morgani include University of Edinburgh & University of Copenhagen.
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Journal ArticleDOI
Totipotent Embryonic Stem Cells Arise in Ground-State Culture Conditions
Sophie M. Morgani,Maurice A. Canham,Jennifer Nichols,Alexei A. Sharov,Rosa Portero Migueles,Minoru S.H. Ko,Minoru S.H. Ko,Joshua M. Brickman,Joshua M. Brickman +8 more
TL;DR: 2i and LIF support a totipotent state comparable to early embryonic cells that coexpress embryonic and extraembryonic determinants, as well as Nanog-positive epiblast-like ESCs.
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TGF-β orchestrates fibrogenic and developmental EMTs via the RAS effector RREB1.
Jie Su,Sophie M. Morgani,Charles J. David,Charles J. David,Qiong Wang,Qiong Wang,Ekrem Emrah Er,Yun-Han Huang,Harihar Basnet,Yilong Zou,Yilong Zou,Weiping Shu,Rajesh K. Soni,Ronald C. Hendrickson,Anna-Katerina Hadjantonakis,Joan Massagué +15 more
TL;DR: RREB1 provides a molecular link between RAS and TGF-β pathways for coordinated induction of developmental and fibrogenic EMTs, and increases the understanding of the regulation of epithelial plasticity and its pathophysiological consequences in development, fibrosis and cancer.
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Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning
Sophie M. Morgani,Sophie M. Morgani,Jakob J. Metzger,Jennifer Nichols,Eric D. Siggia,Anna-Katerina Hadjantonakis +5 more
TL;DR: The mouse micropattern system offers a robust scalable method to generate regionalized cell types present in vivo, resolve how signals promote distinct identities and generate patterns, and compare mechanisms operating in vivo and in vitro and across species.
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The many faces of Pluripotency: in vitro adaptations of a continuum of in vivo states
TL;DR: The continuum of pluripotency existing within the mammalian embryo is discussed, using the mouse as a model, and the cognate stem cell types that can be derived and propagated in vitro are discussed.
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LIF supports primitive endoderm expansion during pre-implantation development.
TL;DR: It is found that activation of JAK/STAT signalling downstream of LIF occurs initially throughout the pre-implantation embryo, but later marks the PrE, suggesting a mechanism by which the embryo adjusts the relative ratio of the primary lineages in response to experimental manipulation.