J
Jalal Ahmed
Researcher at Albert Einstein College of Medicine
Publications - 8
Citations - 2234
Jalal Ahmed is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Bone marrow & Haematopoiesis. The author has an hindex of 4, co-authored 7 publications receiving 1867 citations. Previous affiliations of Jalal Ahmed include Yeshiva University & Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
Arteriolar niches maintain haematopoietic stem cell quiescence
Yuya Kunisaki,Ingmar Bruns,Ingmar Bruns,Christoph Scheiermann,Christoph Scheiermann,Jalal Ahmed,Jalal Ahmed,Sandra Pinho,Dachuan Zhang,Toshihide Mizoguchi,Qiaozhi Wei,Daniel Lucas,Keisuke Ito,Jessica C. Mar,Aviv Bergman,Paul S. Frenette +15 more
TL;DR: It is shown that quiescent HSCs associate specifically with small arterioles that are preferentially found in endosteal bone marrow, indicating that arteriolar niches are indispensable for maintaining HSC quiescence.
Journal ArticleDOI
Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion
Ingmar Bruns,Daniel Lucas,Sandra Pinho,Jalal Ahmed,Michele P. Lambert,Yuya Kunisaki,Christoph Scheiermann,Christoph Scheiermann,Lauren Schiff,Mortimer Poncz,Aviv Bergman,Paul S. Frenette +11 more
TL;DR: It is shown that megakaryocytes (MKs) can directly regulate HSC pool size in mice, indicating that a terminally differentiated cell type derived from HSCs contributes to the HSC niche, directly regulating HSC behavior.
Journal ArticleDOI
CD169⁺ macrophages provide a niche promoting erythropoiesis under homeostasis and stress.
Andrew Chow,Andrew Chow,Matthew A. Huggins,Jalal Ahmed,Jalal Ahmed,Daigo Hashimoto,Daniel Lucas,Yuya Kunisaki,Sandra Pinho,Marylene Leboeuf,Clara Noizat,Clara Noizat,Clara Noizat,Nico van Rooijen,Masato Tanaka,Zhizhuang Joe Zhao,Aviv Bergman,Miriam Merad,Paul S. Frenette +18 more
TL;DR: It is found that specific depletion of CD169+ macrophages markedly reduced the number of erythroblasts in the bone marrow but did not result in overt anemia under homeostatic conditions, probably because of concomitant alterations in red blood cell clearance.
Journal ArticleDOI
Osterix Marks Distinct Waves of Primitive and Definitive Stromal Progenitors during Bone Marrow Development
Toshihide Mizoguchi,Toshihide Mizoguchi,Sandra Pinho,Jalal Ahmed,Jalal Ahmed,Yuya Kunisaki,Maher Hanoun,Avital Mendelson,Noriaki Ono,Henry M. Kronenberg,Paul S. Frenette +10 more
TL;DR: The results uncover a broad expression profile of Osterix and raise the intriguing possibility that distinct waves of stromal cells, primitive and definitive, may organize the developing BM.
Journal ArticleDOI
Megakaryocytes Regulate Hematopoietic Stem Cell Quiescence Via PF4 Secretion
Daniel Lucas,Sandra Pinho,Jalal Ahmed,Michele P. Lambert,Christoph Scheiermann,Yuya Kunisaki,Mortimer Poncz,Paul S. Frenette +7 more
TL;DR: Mk depletion did not result in aberrant hematopoiesis as reflected by WBC and RBC counts in the peripheral blood and progenitor cell numbers in the BM that were indistinguishable from WT mice.