A
Andrew Chow
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 73
Citations - 9444
Andrew Chow is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 23, co-authored 43 publications receiving 7695 citations. Previous affiliations of Andrew Chow include Icahn School of Medicine at Mount Sinai & Albert Einstein College of Medicine.
Papers
More filters
Journal ArticleDOI
Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes
Daigo Hashimoto,Andrew Chow,Andrew Chow,Clara Noizat,Clara Noizat,Pearline Teo,Mary Beth Beasley,Marylene Leboeuf,Christian Becker,Peter See,Jeremy Price,Daniel Lucas,Melanie Greter,Melanie Greter,Arthur Mortha,Scott W. Boyer,E. Camilla Forsberg,Masato Tanaka,Nico van Rooijen,Adolfo García-Sastre,E. Richard Stanley,Florent Ginhoux,Paul S. Frenette,Miriam Merad +23 more
TL;DR: Results indicate that tissue-resident macrophages and circulating monocytes should be classified as mononuclear phagocyte lineages that are independently maintained in the steady state.
Journal ArticleDOI
Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
Emmanuel L. Gautier,Tal Shay,Tal Shay,Jennifer Miller,Melanie Greter,Claudia Jakubzick,Stoyan Ivanov,Julie Helft,Andrew Chow,Kutlu G. Elpek,Simon Gordonov,Amin R. Mazloom,Avi Ma'ayan,Wei-Jen Chua,Ted H. Hansen,Shannon J. Turley,Miriam Merad,Gwendalyn J. Randolph +17 more
TL;DR: It is identified how well-characterized surface markers, including MerTK and FcγR1 (CD64), along with a cluster of previously unidentified transcripts, were distinctly and universally associated with mature tissue macrophages and how these transcripts and the proteins they encode facilitated distinguishing macrophage from dendritic cells.
Journal ArticleDOI
Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses.
Yonit Lavin,Soma Kobayashi,Andrew Leader,El-ad David Amir,Naama Elefant,Camille Bigenwald,Romain Remark,Robert Sweeney,Christian Becker,Jacob H. Levine,Klaus Meinhof,Andrew Chow,Seunghee Kim-Shulze,Andrea S. Wolf,Chiara Medaglia,Hanjie Li,Julie A. Rytlewski,Ryan O. Emerson,Alexander Solovyov,Benjamin Greenbaum,Catherine Sanders,Marissa Vignali,Mary Beth Beasley,Raja M. Flores,Sacha Gnjatic,Dana Pe'er,Adeeb Rahman,Ido Amit,Miriam Merad +28 more
TL;DR: It is shown that stage I lung adenocarcinoma lesions already harbor significantly altered T cell and NK cell compartments, andaired single-cell analyses thus offer valuable knowledge of tumor-driven immune changes, providing a powerful tool for the rational design of immune therapies.
Journal ArticleDOI
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche
Andrew Chow,Daniel Lucas,Daniel Lucas,Andrés Hidalgo,Andrés Hidalgo,Simón Méndez-Ferrer,Simón Méndez-Ferrer,Daigo Hashimoto,Christoph Scheiermann,Christoph Scheiermann,Michela Battista,Marylene Leboeuf,Colette Prophete,Colette Prophete,Nico van Rooijen,Masato Tanaka,Miriam Merad,Paul S. Frenette,Paul S. Frenette +18 more
TL;DR: Results highlight two antagonistic, tightly balanced pathways that regulate maintenance of HSCs/progenitors in the niche during homeostasis, in which MΦ cross talk with the Nestin+ niche cell promotes retention, and in contrast, SNS signals enhance egress.
Journal ArticleDOI
Deciphering the transcriptional network of the dendritic cell lineage
Jennifer Miller,Brian D. Brown,Tal Shay,Emmanuel L. Gautier,Emmanuel L. Gautier,Vladimir Jojic,Vladimir Jojic,Ariella Cohain,Gaurav Pandey,Marylene Leboeuf,Kutlu G. Elpek,Julie Helft,Daigo Hashimoto,Andrew Chow,Andrew Chow,Jeremy Price,Melanie Greter,Melanie Greter,Milena Bogunovic,Angelique Bellemare-Pelletier,Paul S. Frenette,Gwendalyn J. Randolph,Gwendalyn J. Randolph,Shannon J. Turley,Miriam Merad +24 more
TL;DR: A transcriptional program expressed specifically during the steady-state migration of tissue DCs to the draining lymph nodes that may control tolerance to self tissue antigens is identified and predicted regulators of DC functional diversity in tissues are predicted.