R
Rosina T. Lis
Researcher at Harvard University
Publications - 69
Citations - 8297
Rosina T. Lis is an academic researcher from Harvard University. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 29, co-authored 65 publications receiving 6617 citations. Previous affiliations of Rosina T. Lis include Brigham and Women's Hospital & University of Bologna.
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Journal ArticleDOI
Integrative clinical genomics of advanced prostate cancer
Dan R. Robinson,Eliezer M. Van Allen,Eliezer M. Van Allen,Yi-Mi Wu,Nikolaus Schultz,Robert J. Lonigro,Juan Miguel Mosquera,Bruce Montgomery,Mary-Ellen Taplin,Colin C. Pritchard,Gerhardt Attard,Gerhardt Attard,Himisha Beltran,Wassim Abida,Robert K. Bradley,Jake Vinson,Xuhong Cao,Pankaj Vats,Lakshmi P. Kunju,Maha Hussain,Felix Y. Feng,Scott A. Tomlins,Kathleen A. Cooney,David Smith,Christine Brennan,Javed Siddiqui,Rohit Mehra,Yu Chen,Yu Chen,Dana E. Rathkopf,Dana E. Rathkopf,Michael J. Morris,Michael J. Morris,Stephen B. Solomon,Jeremy C. Durack,Victor E. Reuter,Anuradha Gopalan,Jianjiong Gao,Massimo Loda,Rosina T. Lis,Michaela Bowden,Michaela Bowden,Stephen P. Balk,Glenn C. Gaviola,Carrie Sougnez,Manaswi Gupta,Evan Y. Yu,Elahe A. Mostaghel,Heather H. Cheng,Hyojeong Mulcahy,Lawrence D. True,Stephen R. Plymate,Heidi Dvinge,Roberta Ferraldeschi,Roberta Ferraldeschi,Penny Flohr,Penny Flohr,Susana Miranda,Susana Miranda,Zafeiris Zafeiriou,Zafeiris Zafeiriou,Nina Tunariu,Nina Tunariu,Joaquin Mateo,Joaquin Mateo,Raquel Perez-Lopez,Raquel Perez-Lopez,Francesca Demichelis,Francesca Demichelis,Brian D. Robinson,Marc H. Schiffman,David M. Nanus,Scott T. Tagawa,Alexandros Sigaras,Kenneth Eng,Olivier Elemento,Andrea Sboner,Elisabeth I. Heath,Howard I. Scher,Howard I. Scher,Kenneth J. Pienta,Philip W. Kantoff,Johann S. de Bono,Johann S. de Bono,Mark A. Rubin,Peter S. Nelson,Levi A. Garraway,Levi A. Garraway,Charles L. Sawyers,Arul M. Chinnaiyan +89 more
TL;DR: This cohort study provides clinically actionable information that could impact treatment decisions for affected individuals and identified new genomic alterations in PIK3CA/B, R-spondin, BRAF/RAF1, APC, β-catenin, and ZBTB16/PLZF.
Journal ArticleDOI
EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent
Kexin Xu,Zhenhua Jeremy Wu,Anna C. Groner,Housheng Hansen He,Changmeng Cai,Rosina T. Lis,Rosina T. Lis,Xiaoqiu Wu,Edward C. Stack,Edward C. Stack,Massimo Loda,Tao Liu,Han Xu,Laura Cato,James E. Thornton,James E. Thornton,Richard I. Gregory,Richard I. Gregory,Colm Morrissey,Robert L. Vessella,Rodolfo Montironi,Cristina Magi-Galluzzi,Philip W. Kantoff,Steven P. Balk,X. Shirley Liu,Myles Brown +25 more
TL;DR: It is found that the oncogenic function of EZH2 in cells of castration-resistant prostate cancer is independent of its role as a transcriptional repressor, and involves the ability of EzH2 to act as a coactivator for critical transcription factors including the androgen receptor.
Journal ArticleDOI
SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression
Zhihu Ding,Chang-Jiun Wu,Gerald C. Chu,Yonghong Xiao,Dennis Ho,J. Zhang,Samuel R. Perry,Emma S. Labrot,Xiaoqiu Wu,Rosina T. Lis,Yujin Hoshida,David Hiller,Baoli Hu,Shan Jiang,Hongwu Zheng,Alexander H. Stegh,Kenneth L. Scott,Sabina Signoretti,Nabeel Bardeesy,Y. Alan Wang,David E. Hill,Todd R. Golub,Meir J. Stampfer,Wing Hung Wong,Massimo Loda,Lorelei A. Mucci,Lynda Chin,Ronald A. DePinho +27 more
TL;DR: This model-informed progression analysis, together with genetic, functional and translational studies, establishes SMAD4 as a key regulator of PCA progression in mice and humans.
Journal ArticleDOI
Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer
Jens G. Lohr,Jens G. Lohr,Viktor A. Adalsteinsson,Viktor A. Adalsteinsson,Kristian Cibulskis,Atish D. Choudhury,Atish D. Choudhury,Mara Rosenberg,Peter Cruz-Gordillo,Joshua M. Francis,Joshua M. Francis,Cheng-Zhong Zhang,Cheng-Zhong Zhang,Alex K. Shalek,Rahul Satija,John J. Trombetta,Diana Lu,Naren Tallapragada,Narmin Tahirova,Sora Kim,Brendan Blumenstiel,Carrie Sougnez,Alarice C. Lowe,Bang Wong,Daniel Auclair,Eliezer M. Van Allen,Eliezer M. Van Allen,Mari Nakabayashi,Rosina T. Lis,Gwo-Shu Mary Lee,Tiantian Li,Matthew S. Chabot,Amy Ly,Mary-Ellen Taplin,Thomas E. Clancy,Thomas E. Clancy,Massimo Loda,Aviv Regev,Aviv Regev,Aviv Regev,Matthew Meyerson,Matthew Meyerson,William C. Hahn,Philip W. Kantoff,Todd R. Golub,Gad Getz,Gad Getz,Jesse S. Boehm,J. Christopher Love,J. Christopher Love,J. Christopher Love +50 more
TL;DR: In this paper, whole-exome sequencing of circulating tumor cells enables accurate and powered calling of somatic point mutations, and the authors propose a method to identify the source of the point mutations.
Journal ArticleDOI
Erratum: Integrative Clinical Genomics of Advanced Prostate Cancer
Dan R. Robinson,Eliezer M. Van Allen,Yi-Mi Wu,Nikolaus Schultz,Robert J. Lonigro,Juan Miguel Mosquera,Bruce Montgomery,Mary-Ellen Taplin,Colin C. Pritchard,Gerhardt Attard,Himisha Beltran,Wassim Abida,Robert K. Bradley,Jake Vinson,Xuhong Cao,Pankaj Vats,Lakshmi P. Kunju,Maha Hussain,Felix Y. Feng,Scott A. Tomlins,Kathleen A. Cooney,David Smith,Christine Brennan,Javed Siddiqui,Rohit Mehra,Yu Chen,Dana E. Rathkopf,Michael J. Morris,Stephen B. Solomon,Jeremy C. Durack,Victor E. Reuter,Anuradha Gopalan,Jianjiong Gao,Massimo Loda,Rosina T. Lis,Michaela Bowden,Stephen P. Balk,Glenn C. Gaviola,Carrie Sougnez,Manaswi Gupta,Evan Y. Yu,Elahe A. Mostaghel,Heather H. Cheng,Hyojeong Mulcahy,Lawrence D. True,Stephen R. Plymate,Heidi Dvinge,Roberta Ferraldeschi,Penny Flohr,Susana Miranda,Zafeiris Zafeiriou,Nina Tunariu,Joaquin Mateo,Raquel Perez-Lopez,Francesca Demichelis,Brian D. Robinson,Andrea Sboner,Marc H. Schiffman,David M. Nanus,Scott T. Tagawa,Alexandros Sigaras,Kenneth Eng,Olivier Elemento,Elisabeth I. Heath,Howard I. Scher,Kenneth J. Pienta,Philip W. Kantoff,Johann S. de Bono,Mark A. Rubin,Peter S. Nelson,Levi A. Garraway,Charles L. Sawyers,Arul M. Chinnaiyan +72 more
TL;DR: Dan Robinson, Eliezer M. Robinson, Andrea Sboner, Marc Schiffman, David M. Smith, Christine Brennan, Javed Siddiqui, Rohit Mehra, Yu Chen, Dana E. Rathkopf, Michael J. Morris, Stephen B. Solomon, Jeremy C. Tomlins, Kathleen A. Reuter, Anuradha Gopalan, Jianjiong Gao, Massimo Loda, Rosina T.