James G. Lefevre

TL;DR: A comprehensive, quantitative, multiscale analysis of mammalian kidney development in which changes in cell number, compartment volumes, and cellular dynamics across the entirety of organogenesis are measured, focusing on two key nephrogenic progenitor populations: the ureteric epithelium and the cap mesenchyme.

TL;DR: It is demonstrated that N-WASP enhances apical junctional tension by stabilizing local F-actin networks, which otherwise undergo stress-induced turnover and is proposed to regulate the landscape of intra-junctional contractility to determine whether or not cells integrate into epithelial populations.

TL;DR: It is proved that the slope parameter of the ordinary least squares regression of phylogenetically independent contrasts (PICs) conducted through the origin is identical to the slope parameters of the method of generalized least squares (GLSs) regression under a Brownian motion model of evolution.

TL;DR: Characterising the tissue by classifying it into 12 meaningful dermatological classes, including hair follicles, sweat glands as well as identifying the well-defined stratified layers of the skin helps inform ways in which future computer aided diagnosis systems could be applied usefully in a clinical setting with human interpretable outcomes.

TL;DR: Using ex vivo timelapse imaging, it is shown that cells of the cap mesenchyme are highly motile, and that the resulting swarming behaviour maintains a distinct cap meschyme domain while facilitating dynamic remodelling in response to underlying changes in the tip.