J
James J. Burston
Researcher at University of Nottingham
Publications - 49
Citations - 3788
James J. Burston is an academic researcher from University of Nottingham. The author has contributed to research in topics: Osteoarthritis & Cannabinoid receptor. The author has an hindex of 24, co-authored 47 publications receiving 3302 citations. Previous affiliations of James J. Burston include Virginia Commonwealth University & University of the West of England.
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Journal ArticleDOI
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects
Jonathan Z. Long,Weiwei Li,Lamont Booker,James J. Burston,Steven G. Kinsey,Joel E. Schlosburg,Franciso J Pavón,Antonia Serrano,Dana E. Selley,Loren H. Parsons,Aron H. Lichtman,Benjamin F. Cravatt +11 more
TL;DR: 2-AG endogenously modulates several behavioral processes classically associated with the pharmacology of cannabinoids and point to overlapping and unique functions for 2-AG and anandamide in vivo, indicating a functional segregation of endocannabinoid signaling pathways in vivo.
Journal ArticleDOI
Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system
Joel E. Schlosburg,Jacqueline L. Blankman,Jonathan Z. Long,Daniel K. Nomura,Bin Pan,Steven G. Kinsey,Peter T. Nguyen,Divya Ramesh,Lamont Booker,James J. Burston,Elizabeth A. Thomas,Dana E. Selley,Laura J. Sim-Selley,Qing-song Liu,Aron H. Lichtman,Benjamin F. Cravatt +15 more
TL;DR: Individual endocannabinoids generate distinct analgesic profiles that are either sustained or transitory and associated with agonism and functional antagonism of the brain cannabinoid system, respectively.
Journal ArticleDOI
Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo
Jonathan Z. Long,Daniel K. Nomura,Robert E. Vann,D. Matthew Walentiny,Lamont Booker,Xin Jin,James J. Burston,Laura J. Sim-Selley,Aron H. Lichtman,Jenny L. Wiley,Benjamin F. Cravatt +10 more
TL;DR: A selective and efficacious dual FAAH/MAGL inhibitor is described and it is shown that this agent exhibits broad activity in the tetrad test for CB1 agonism, causing analgesia, hypomotilty, and catalepsy, indicating that AEA and 2-AG signaling pathways interact to regulate specific behavioral processes in vivo, including those relevant to drug abuse.
Journal ArticleDOI
CB1 cannabinoid receptor-mediated modulation of food intake in mice
Jenny L. Wiley,James J. Burston,Darnica C Leggett,Olga O. Alekseeva,Raj K. Razdan,Anu Mahadevan,Billy R. Martin +6 more
TL;DR: The results strongly suggest that CB1 receptors may play a role in regulation of feeding behavior and that SR141716A may affect the actions of endogenous cannabinoids in regulating appetite.
Journal ArticleDOI
Regional enhancement of cannabinoid CB1 receptor desensitization in female adolescent rats following repeated Δ9-tetrahydrocannabinol exposure
James J. Burston,James J. Burston,Jenny L. Wiley,Jenny L. Wiley,Abimbola A Craig,Dana E. Selley,Laura J. Sim-Selley +6 more
TL;DR: Whether adolescent and adult rats exhibit differential adaptation of brain cannabinoid (CB1) receptors after repeated exposure to Δ9‐tetrahydrocannabinol (THC) is determined.