J
James L. Weber
Researcher at Marshfield Clinic
Publications - 172
Citations - 31142
James L. Weber is an academic researcher from Marshfield Clinic. The author has contributed to research in topics: Gene mapping & Locus (genetics). The author has an hindex of 70, co-authored 172 publications receiving 30301 citations. Previous affiliations of James L. Weber include QIMR Berghofer Medical Research Institute & Walter Reed Army Institute of Research.
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Journal Article
Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction
James L. Weber,P E May +1 more
TL;DR: It is reported that specific human (dC-dA)n.(dG-dT)n blocks are polymorphic in length among individuals and therefore represent a vast new pool of potential genetic markers.
Journal ArticleDOI
Genetic Structure of Human Populations
Noah A. Rosenberg,Jonathan K. Pritchard,James L. Weber,Howard M. Cann,Kenneth K. Kidd,Lev A. Zhivotovsky,Marcus W. Feldman +6 more
TL;DR: General agreement of genetic and predefined populations suggests that self-reported ancestry can facilitate assessments of epidemiological risks but does not obviate the need to use genetic information in genetic association studies.
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Mutation of human short tandem repeats
James L. Weber,Carmen Wong +1 more
TL;DR: A total of 20,000 parent-offspring transfers of alleles were examined through the genotyping within 40 CEPH reference families of 28 short tandem repeat polymorphisms (STRPs) located on chromosome 19, and the average mutation rate was nearly four times higher than the average rate for dinucleotide STRPs.
Journal ArticleDOI
The Genetic Structure and History of Africans and African Americans
Sarah A. Tishkoff,Floyd A. Reed,Françoise R. Friedlaender,Christopher Ehret,Alessia Ranciaro,Alessia Ranciaro,Alessia Ranciaro,Alain Froment,Jibril Hirbo,Jibril Hirbo,Agnes A. Awomoyi,Jean-Marie Bodo,Ogobara K. Doumbo,Muntaser E. Ibrahim,Abdalla T. Juma,Maritha J. Kotze,Godfrey Lema,Jason H. Moore,Holly M. Mortensen,Thomas B. Nyambo,Sabah A. Omar,Kweli Powell,Gideon S. Pretorius,Michael W. Smith,Mahamadou A. Thera,Charles Wambebe,James L. Weber,Scott M. Williams +27 more
TL;DR: A detailed genetic analysis of most major groups of African populations is provided, suggesting that Africans represent 14 ancestral populations that correlate with self-described ethnicity and shared cultural and/or linguistic properties.
Journal ArticleDOI
Informativeness of human (dC-dA)n.(dG-dT)n polymorphisms.
TL;DR: The longest run of uninterrupted CA or GT repeats was found to be the best predictor of informativeness of (dC-dA)n.(dG-dT)n polymorphisms regardless of the repeat sequence category.