J
James Sneyd
Researcher at University of Auckland
Publications - 186
Citations - 11960
James Sneyd is an academic researcher from University of Auckland. The author has contributed to research in topics: Inositol trisphosphate receptor & Calcium. The author has an hindex of 46, co-authored 180 publications receiving 11251 citations. Previous affiliations of James Sneyd include University of California, Los Angeles & University of Michigan.
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A Mathematical Model of Airway and Pulmonary Arteriole Smooth Muscle
TL;DR: It is predicted that oscillations in calcium concentration, commonly observed during agonist-induced smooth muscle contraction, cause a significantly greater contraction than an elevated steady calcium concentration and that murine airway SMCs exploit a Ca2+-dependent mechanism to favor a default state of relaxation.
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The native ORAI channel trio underlies the diversity of Ca 2+ signaling events
Ryan E. Yoast,Scott M. Emrich,Xuexin Zhang,Ping Xin,Martin Johnson,Adam J. Fike,Vonn Walter,Nadine Hempel,David I. Yule,James Sneyd,Donald L. Gill,Mohamed Trebak +11 more
TL;DR: The results uncover an intricate control mechanism whereby heteromerization of ORAI channels mediates graded Ca2+ signals that extend the agonist-sensitivity to fine-tune transcriptional control.
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Multiple Timescales, Mixed Mode Oscillations and Canards in Models of Intracellular Calcium Dynamics
TL;DR: Analysis of the number and nature of the distinct timescales in a model allows us to make useful predictions about the dynamics associated with the model, and may give us more information about the model dynamics than a classification according to the modelling assumptions made about different cellular mechanisms in deriving the models.
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A Kinetic Model for Type I and II IP3R Accounting for Mode Changes
TL;DR: A compact representation of the IP(3)R is obtained that accurately captures stochastic single-channel dynamics including mode changes in a model with six states and 10 rate constants, only two of which are ligand-dependent.
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Two-dimensional model of calcium waves reproduces the patterns observed in Xenopus oocytes.
TL;DR: Extending an existing ordinary differential equation model of Ca2+ oscillations to two spatial dimensions, this work develops a partial differential equation (PDE) model ofCa2+ excitability that qualitatively reproduces the experimental observations.