J
James Sneyd
Researcher at University of Auckland
Publications - 186
Citations - 11960
James Sneyd is an academic researcher from University of Auckland. The author has contributed to research in topics: Inositol trisphosphate receptor & Calcium. The author has an hindex of 46, co-authored 180 publications receiving 11251 citations. Previous affiliations of James Sneyd include University of California, Los Angeles & University of Michigan.
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Journal ArticleDOI
A mathematical model of fluid secretion from a parotid acinar cell.
TL;DR: It is found that [Ca(2+)] oscillations lead to oscillations in fluid flow, and that the rate of fluid flow is regulated by the average calcium concentration and not the frequency of the oscillations.
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Omnitemporal choreographies of all five STIM/Orai and IP3Rs underlie the complexity of mammalian Ca2+ signaling.
Scott M. Emrich,Ryan E. Yoast,Ping Xin,Vikas Arige,Larry E. Wagner,Nadine Hempel,Donald L. Gill,James Sneyd,David I. Yule,Mohamed Trebak +9 more
TL;DR: In this article, the authors show that the five STIM1/2 and Orai1 2/2/3 proteins are non-redundant and function together to ensure the graded diversity of mammalian Ca2+ signaling.
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Homogenization of the cell cytoplasm: the calcium bidomain equations ∗
TL;DR: A bidomain model of calcium concentration inside the ER network, and outside it, in the cytosol is derived and the homogenized macroscopic behavior is described in a two-concentration field model.
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A biomechanical model of agonist-initiated contraction in the asthmatic airway
Bindi S. Brook,Samantha Peel,Ian P. Hall,Antonio Z. Politi,James Sneyd,Yan Bai,Michael J. Sanderson,Oliver E. Jensen +7 more
TL;DR: A modelling framework in which the local stress environment of airway smooth muscle cells may be predicted and cellular responses to local stress may be investigated is presented, finding that radial and hoop-stress distributions in remodelled muscle layers are highly heterogenous with distinct regions of compression and tension.
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A comparison of three models of the inositol trisphosphate receptor.
TL;DR: Three mathematical models of the inositol (1,4,5)-trisphosphate receptor (IPR) are compared, indicating that fast activation of the receptor, followed by slow inactivation, is an important feature of the model, and also that the speed of inositl trisph phosphate IP3 binding cannot necessarily be assumed to be faster than Ca2+ activation.