J
Jamie Near
Researcher at Douglas Mental Health University Institute
Publications - 102
Citations - 3883
Jamie Near is an academic researcher from Douglas Mental Health University Institute. The author has contributed to research in topics: Medicine & Glutamate receptor. The author has an hindex of 28, co-authored 86 publications receiving 2823 citations. Previous affiliations of Jamie Near include University of Oxford & McGill University.
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Journal ArticleDOI
Structural and functional imaging of the hippocampus in young people at familial risk of depression
TL;DR: Euthymic individuals with a parental history of depression demonstrate increased activation of hippocampal-related neural networks during a memory task, particularly in brain regions involved in processing the salience of stimuli.
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Correcting frequency and phase offsets in MRS data using robust spectral registration
Mark Mikkelsen,Mark Mikkelsen,Sofie Tapper,Sofie Tapper,Jamie Near,Stewart H. Mostofsky,Stewart H. Mostofsky,Nicolaas A.J. Puts,Nicolaas A.J. Puts,Nicolaas A.J. Puts,Richard A.E. Edden,Richard A.E. Edden +11 more
TL;DR: The algorithm, termed robust spectral registration (rSR), contains a set of subroutines designed to robustly align individual transients in a given dataset even in cases of significant frequency and phase offsets or unstable lipid contamination and residual water signals.
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Effect of age and the APOE gene on metabolite concentrations in the posterior cingulate cortex.
Sana Suri,Uzay E. Emir,Charlotte J. Stagg,Jamie Near,Ralf Mekle,Florian Schubert,Enikő Zsoldos,Abda Mahmood,Archana Singh-Manoux,Mika Kivimäki,Klaus P. Ebmeier,Clare E. Mackay,Nicola Filippini +12 more
TL;DR: The data suggest that creatine, a commonly used reference metabolite in 1H‐MRS studies, does not remain stable across adulthood within this region and therefore may not be a suitable reference in studies involving a broad age‐range.
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Early increase in marker of neuronal integrity with antidepressant treatment of major depression: 1H-magnetic resonance spectroscopy of N-acetyl-aspartate
TL;DR: Levels of NAA were significantly higher in patients treated with escitalopram than in either placebo-treated patients or healthy controls, consistent with the proposition that antidepressant treatment in depressed patients can produce early changes in neuronal integrity.
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Magnetic resonance (MR) spectroscopic measurement of γ-aminobutyric acid (GABA) in major depression before and after electroconvulsive therapy
TL;DR: This study does not support prior studies arguing for GABA as a key factor in the treatment effect of ECT on major depression, and observed a significant decrease in NAA levels following ECT, due to neuronal loss or a transient dysfunction in prefrontal cortex.