Jamie Near

TL;DR: The higher concentration of GABA in GM than in WM found in this study and literature might be reflective of heterogeneous distribution of GABA around the brain.

TL;DR: StandardRat is introduced, a consensus rat functional MRI acquisition protocol that enhances biologically plausible functional connectivity patterns, relative to pre-existing acquisitions, and is openly shared with the neuroimaging community to promote interoperability and cooperation towards tackling the most important challenges in neuroscience.

TL;DR: It is demonstrated that the MRS-measured Glu and GABA can reflect spontaneous and stimulated activities of neurons producing and releasing these neurotransmitters in an awake condition.

TL;DR: StandardRat as mentioned in this paper is a consensus rat functional magnetic resonance imaging acquisition protocol tested across 20 centers and showed that the standardized protocol enhances biologically plausible functional connectivity patterns relative to previous acquisitions, and is openly shared with the neuroimaging community to promote interoperability and cooperation toward tackling the most important challenges in neuroscience.

TL;DR: Findings support the use of MRI and magnetic resonance spectroscopy for the development of non-invasive biomarkers of disease progression, clarify the timing of pathological feature presentation in this model, and contribute to the validation of the TgF344-AD rat as a highly relevant model for pre-clinical Alzheimer’s disease research.