Jan-Erling Bäckvall

TL;DR: The use of coupled catalytic systems with electron-transfer mediators usually facilitates the procedures by transporting the electrons from the catalyst to the oxidant along a low-energy pathway, thereby increasing the efficiency of the oxidation and thus complementing the direct oxidation reactions.

TL;DR: A deeper understanding of the compatibility of these two catalysts has been achieved and the limitation of the maximum 50% yield in a kinetic resolution is overcomes by combining it with an in situ racemization of the substrate.

TL;DR: The X-ray structure of lipase A from Candida antarctica is reported, solved by single isomorphous replacement with anomalous scattering, and refined to 2.2-A resolution, providing a basis for understanding the enzyme's preference for acyl moieties with long, straight tails, and for its highly promiscuous acceptance of widely different alcohol and amine moieties.

TL;DR: The chemoenzymatic DKR protocol was applied to the synthesis of norsertraline by using a novel route starting from readily available 1,2,3,4-tetrahydro-1-naphthylamine (1 o) and support that the rate-determining step is beta-hydride elimination.

TL;DR: The kinetic isotope effects observed support a stepwise hydrogen transfer where the isotope effect for C-H cleavage is equal to the combined (C-H, N-H) isotopeeffect (k(CHNH)/k(CDND) = 3.26).