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Patrik Johansson
Researcher at AstraZeneca
Publications - 70
Citations - 11957
Patrik Johansson is an academic researcher from AstraZeneca. The author has contributed to research in topics: Chemistry & Electrolyte. The author has an hindex of 24, co-authored 55 publications receiving 9309 citations. Previous affiliations of Patrik Johansson include Lund University & University of Gothenburg.
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Journal ArticleDOI
The cancer genome atlas pan-cancer analysis project
John N. Weinstein,John N. Weinstein,Eric A. Collisson,Gordon B. Mills,Kenna R. Mills Shaw,Kenna R. Mills Shaw,Brad Ozenberger,Kyle Ellrott,Kyle Ellrott,Chris Sander,Joshua M. Stuart,Joshua M. Stuart,Kyle Chang,Chad J. Creighton,Caleb F. Davis,Lawrence A. Donehower,Jennifer Drummond,David A. Wheeler,Adrian Ally,Miruna Balasundaram,Inanc Birol,Inanc Birol,Inanc Birol,Yaron S.N. Butterfield,Andy Chu,Eric Chuah,Hye Jung E. Chun,Noreen Dhalla,Ranabir Guin,Martin Hirst,Carrie Hirst,Robert A. Holt,Steven J.M. Jones,Darlene Lee,Haiyan I. Li,Marco A. Marra,Michael Mayo,Richard A. Moore,Andrew J. Mungall,A. Gordon Robertson,Jacqueline E. Schein,Payal Sipahimalani,Angela Tam,Nina Thiessen,Richard Varhol,Rameen Beroukhim,Ami S. Bhatt,Angela N. Brooks,Andrew D. Cherniack,Samuel S. Freeman,Stacey Gabriel,Elena Helman,Joonil Jung,Matthew Meyerson,Akinyemi I. Ojesina,Chandra Sekhar Pedamallu,Gordon Saksena,Steven E. Schumacher,Barbara Tabak,Travis I. Zack,Travis I. Zack,Eric S. Lander,Christopher A. Bristow,Angela Hadjipanayis,Psalm Haseley,Raju Kucherlapati,Semin Lee,Eunjung Lee,Lovelace J. Luquette,Harshad S. Mahadeshwar,Angeliki Pantazi,Michael Parfenov,Michael Parfenov,Peter J. Park,Alexei Protopopov,Xiaojia Ren,Netty Santoso,Jonathan G. Seidman,Sahil Seth,Xingzhi Song,Jiabin Tang,Ruibin Xi,Ruibin Xi,Ruibin Xi,Andrew Wei Xu,Lixing Yang,Dong Zeng,J. Todd Auman,Saianand Balu,Elizabeth Buda,Cheng Fan,Katherine A. Hoadley,Corbin D. Jones,Shaowu Meng,Piotr A. Mieczkowski,Joel S. Parker,Charles M. Perou,Jeffrey Roach,Yan Shi,Grace O. Silva,Donghui Tan,Umadevi Veluvolu,Scot Waring,Matthew D. Wilkerson,Junyuan Wu,Wei Zhao,Tom Bodenheimer,D. Neil Hayes,D. Neil Hayes,Alan P. Hoyle,Stuart R. Jeffreys,Lisle E. Mose,Janae V. Simons,Mathew G. Soloway,Stephen B. Baylin,Benjamin P. Berman,Moiz S. Bootwalla,Ludmila Danilova,James G. Herman,Toshinori Hinoue,Peter W. Laird,Suhn K. Rhie,Hui Shen,Timothy J. Triche,Daniel J. Weisenberger,Scott L. Carter,Kristian Cibulskis,Lynda Chin,Jianhua Zhang,Carrie Sougnez,Min Wang,Gad Getz,Gad Getz,Huyen Dinh,Harshavardhan Doddapaneni,Richard A. Gibbs,Preethi Gunaratne,Preethi Gunaratne,Yi Han,Divya Kalra,Christie Kovar,Lora Lewis,Margaret B. Morgan,Donna Morton,Donna Muzny,Jeffrey G. Reid,Liu Xi,Juok Cho,Daniel DiCara,Scott Frazer,Nils Gehlenborg,David I. Heiman,Jaegil Kim,Michael S. Lawrence,Pei Lin,Yingchun Liu,Michael S. Noble,Petar Stojanov,Doug Voet,Hailei Zhang,Lihua Zou,Chip Stewart,Brady Bernard,Ryan Bressler,Andrea Eakin,Lisa Iype,Theo A. Knijnenburg,Roger Kramer,Richard Kreisberg,Kalle Leinonen,Jake Lin,Yuexin Liu,Michael Miller,Sheila M. Reynolds,Hector Rovira,Ilya Shmulevich,Vesteinn Thorsson,Da Yang,Wei Zhang,Samirkumar B. Amin,Chang-Jiun Wu,Chia Chin Wu,Rehan Akbani,Kenneth Aldape,Keith A. Baggerly,Bradley McIntosh Broom,Tod D. Casasent,James Cleland,Deepti Dodda,Mary Elizabeth Edgerton,Leng Han,Shelley M. Herbrich,Zhenlin Ju,Hoon Kim,Hoon Kim,Seth Lerner,Jun Li,Han Liang,Wenbin Liu,Philip L. Lorenzi,Yiling Lu,James M. Melott,Lam Nguyen,Lam Nguyen,Xiaoping Su,Roeland Verhaak,Wenyi Wang,Andrew J. Wong,Andrew J. Wong,Yang Yang,Jun Yao,Rong Yao,Kosuke Yoshihara,Yuan Yuan,Yuan Yuan,W. K. Alfred Yung,Nianxiang Zhang,Siyuan Zheng,Michael B. Ryan,Michael B. Ryan,David W. Kane,David W. Kane,B. Arman Aksoy,Giovanni Ciriello,Gideon Dresdner,Jianjiong Gao,Benjamin Gross,Anders Jacobsen,André Kahles,Marc Ladanyi,William Lee,Kjong-Van Lehmann,Martin L. Miller,Ricardo Ramirez,Gunnar Rätsch,Boris Reva,Nikolaus Schultz,Yasin Senbabaoglu,Ronglai Shen,Rileen Sinha,S. Onur Sumer,Yichao Sun,Barry S. Taylor,Barry S. Taylor,Barry S. Taylor,Nils Weinhold,Suzanne S. Fei,Paul T. Spellman,Christopher C. Benz,Christopher C. Benz,Daniel E. Carlin,Daniel E. Carlin,Melisssa Cline,Melisssa Cline,Brian Craft,Brian Craft,Mary Goldman,David Haussler,David Haussler,David Haussler,Singer Ma,Singer Ma,Sam Ng,Sam Ng,Evan O. Paull,Evan O. Paull,Amie Radenbaugh,Amie Radenbaugh,Sofie R. Salama,Sofie R. Salama,Sofie R. Salama,Artem Sokolov,Artem Sokolov,Teresa Swatloski,Teresa Swatloski,Vladislav Uzunangelov,Vladislav Uzunangelov,Peter Waltman,Peter Waltman,Christina Yau,Jing Zhu,Jing Zhu,Stanley R. Hamilton,Scott Abbott,Rachel Abbott,Nathan D. Dees,Kim D. Delehaunty,Li Ding,David J. Dooling,James M. Eldred,Catrina Fronick,Robert S. Fulton,Lucinda Fulton,Joelle Kalicki-Veizer,Krishna L. Kanchi,Cyriac Kandoth,Daniel C. Koboldt,David E. Larson,Timothy J. Ley,Ling Lin,Charles Lu,Vincent Magrini,Elaine R. Mardis,Michael D. McLellan,Joshua F. McMichael,Christopher A. Miller,Michelle O'Laughlin,Craig Pohl,Heather Schmidt,Scott M. Smith,Jason Walker,John W. Wallis,Michael C. Wendl,Michael C. Wendl,Richard K. Wilson,Todd Wylie,Qunyuan Zhang,Robert A. Burton,Mark A. Jensen,Ari B. Kahn,Todd Pihl,David A. Pot,Yunhu Wan,Douglas A. Levine,Aaron D. Black,Jay Bowen,Jessica Frick,Julie M. Gastier-Foster,Julie M. Gastier-Foster,Hollie A. Harper,Carmen Helsel,Kristen M. Leraas,Tara M. Lichtenberg,Cynthia McAllister,Nilsa C. Ramirez,Nilsa C. Ramirez,Samantha Sharpe,Lisa Wise,Erik Zmuda,Stephen J. Chanock,Tanja Davidsen,John A. Demchok,Greg Eley,Ina Felau,Margi Sheth,Heidi J. Sofia,Louis M. Staudt,Roy Tarnuzzer,Zhining Wang,Liming Yang,Jiashan Zhang,Larsson Omberg,Adam Margolin,Benjamin J. Raphael,Fabio Vandin,Hsin-Ta Wu,Mark D.M. Leiserson,Stephen C. Benz,Charles J. Vaske,Houtan Noushmehr,Houtan Noushmehr,Denise M. Wolf,Laura van 't Veer,Dimitris Anastassiou,Tai Hsien Ou Yang,Nuria Lopez-Bigas,Abel Gonzalez-Perez,David Tamborero,Zheng Xia,Wei Li,Dong Yeon Cho,Teresa M. Przytycka,Mark P. Hamilton,Sean E. McGuire,Sven Nelander,Sven Nelander,Patrik Johansson,Rebecka Jörnsten,Rebecka Jörnsten,Teresia Kling +379 more
TL;DR: The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA with a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages.
Journal Article
The Cancer Genome Atlas Pan-Cancer analysis project
Kyle Chang,Chad J Creighton,Caleb F. Davis,Lawrence A. Donehower,Jennifer Drummond,David A. Wheeler,Adrian Ally,Miruna Balasundaram,Inanc Birol,Yaron S.N. Butterfield,Andy Chu,Eric Chuah,Hye Jung E. Chun,Noreen Dhalla,Ranabir Guin,Martin Hirst,Carrie Hirst,Robert A. Holt,Steven J.M. Jones,Darlene Lee,Haiyan I. Li,Marco A. Marra,Michael Mayo,Richard A. Moore,Andrew J. Mungall,A. Gordon Robertson,Jacqueline E. Schein,Payal Sipahimalani,Angela Tam,Nina Thiessen,Richard Varhol,Rameen Beroukhim,Ami S. Bhatt,Angela N. Brooks,Andrew D. Cherniack,Samuel S. Freeman,Stacey Gabriel,Elena Helman,Joonil Jung,Matthew Meyerson,Akinyemi I. Ojesina,Chandra Sekhar Pedamallu,Gordon Saksena,Steven E. Schumacher,Barbara Tabak,Travis I. Zack,Eric S. Lander,Christopher A. Bristow,Angela Hadjipanayis,Psalm Haseley,Raju Kucherlapati,Semin Lee,Eunjung Lee,Lovelace J. Luquette,Harshad S. Mahadeshwar,Angeliki Pantazi,Michael Parfenov,Peter J. Park,Alexei Protopopov,Xiaojia Ren,Netty Santoso,Jonathan G. Seidman,Sahil Seth,Xingzhi Song,Jiabin Tang,Ruibin Xi,Andrew Wei Xu,Lixing Yang,Dong Zeng,J. Todd Auman,Saianand Balu,Elizabeth Buda,Cheng Fan,Katherine A. Hoadley,Corbin D. Jones,Shaowu Meng,Piotr A. Mieczkowski,Joel S. Parker,Charles M. Perou,Jeffrey Roach,Yan Shi,Grace O. Silva,Donghui Tan,Umadevi Veluvolu,Scot Waring,Matthew D. Wilkerson,Junyuan Wu,Wei Zhao,Tom Bodenheimer,D. Neil Hayes,Alan P. Hoyle,Stuart R. Jeffreys,Lisle E. Mose,Janae V. Simons,Mathew G. Soloway,Stephen B. Baylin,Benjamin P. Berman,Moiz S. Bootwalla,Ludmila Danilova,James G. Herman,Toshinori Hinoue,Peter W. Laird,Suhn K. Rhie,Hui Shen,Timothy J. Triche,Daniel J. Weisenberger,Scott L. Carter,Kristian Cibulskis,Lynda Chin,Jianhua Zhang,Gad Getz,Carrie Sougnez,Min Wang,Huyen Dinh,Harshavardhan Doddapaneni,Richard A. Gibbs,Preethi H. Gunaratne,Yi Han,Divya Kalra,Christie Kovar,Lora Lewis,Margaret Morgan,Donna Morton,Donna M. Muzny,Jeffrey G. Reid,Liu Xi,Juok Cho,Daniel DiCara,Scott Frazer,Nils Gehlenborg,David I. Heiman,Jaegil Kim,Michael S. Lawrence,Pei Lin,Yingchun Liu,Michael S. Noble,Petar Stojanov,Doug Voet,Hailei Zhang,Lihua Zou,Chip Stewart,Brady Bernard,Ryan Bressler,Andrea Eakin,Lisa Iype,Theo A. Knijnenburg,Roger Kramer,Richard Kreisberg,Kalle Leinonen,Jake Lin,Yuexin Liu,Michael W. Miller,Sheila Reynolds,Hector Rovira,Ilya Shmulevich,Vesteinn Thorsson,Da Yang,Wei Zhang,Samirkumar B. Amin,Chang-Jiun Wu,Chia Chin Wu,Rehan Akbani,Kenneth Aldape,Keith A. Baggerly,Bradley M. Broom,Tod D. Casasent,James Cleland,Chad J. Creighton,Deepti Dodda,Mary E. Edgerton,Leng Han,Shelley M. Herbrich,Zhenlin Ju,Hoon Kim,Seth P. Lerner,Jun Li,Han Liang,Wen-Bin Liu,Philip L. Lorenzi,Yiling Lu,James M. Melott,Gordon B. Mills,Lam Nhat Nguyen,Xiaoping Su,Roeland Verhaak,Wenyi Wang,John N. Weinstein,Andrew Wong,Yang Yang,Jun Yao,Rong Yao,Kosuke Yoshihara,Yuan Yuan,Alfred K Yung,Nianxiang Zhang,Siyuan Zheng,Michael T. Ryan,David W. Kane,B. Arman Aksoy,Giovanni Ciriello,Gideon Dresdner,Jianjiong Gao,Benjamin Gross,Anders Jacobsen,André Kahles,Marc Ladanyi,William H. Lee,Kjong-Van Lehmann,Martin L. Miller,Ricardo Ramirez,Gunnar Rätsch,Boris Reva,Chris Sander,Nikolaus Schultz,Yasin Senbabaoglu,Ronglai Shen,Rileen Sinha,S. Onur Sumer,Yichao Sun,Barry S. Taylor,Nils Weinhold,Suzanne S. Fei,Paul T. Spellman,Christopher C. Benz,Daniel E. Carlin,Melisssa Cline,Brian Craft,Kyle Ellrott,Mary Goldman,David Haussler,Singer Ma,Sam Ng,Evan O. Paull,Amie Radenbaugh,Sofie R. Salama,Artem Sokolov,Joshua M. Stuart,Teresa Swatloski,Vladislav Uzunangelov,Peter Waltman,Christina Yau,Jing Zhu,Stanley R. Hamilton,Scott Abbott,Rachel Abbott,Nathan D. Dees,Kim D. Delehaunty,Li Ding,David J. Dooling,James M. Eldred,Catrina Fronick,Robert S. Fulton,Lucinda Fulton,Joelle Kalicki-Veizer,Krishna-Latha Kanchi,Cyriac Kandoth,Daniel C. Koboldt,David E. Larson,Timothy J. Ley,Ling Lin,Charles Lu,Vincent Magrini,Elaine R. Mardis,Michael D. McLellan,Joshua F. McMichael,Christopher A. Miller,Michelle O'Laughlin,Craig Pohl,Heather Schmidt,Scott M. Smith,Jason Walker,John W. Wallis,Michael C. Wendl,Richard K. Wilson,Todd Wylie,Qunyuan Zhang,Robert A. Burton,Mark A. Jensen,Ari B. Kahn,Todd Pihl,David Pot,Yunhu Wan,Douglas A. Levine,Aaron D. Black,Jay Bowen,Jessica Frick,Julie M. Gastier-Foster,Hollie A. Harper,Carmen Helsel,Kristen M. Leraas,Tara M. Lichtenberg,Cynthia McAllister,Nilsa C. Ramirez,Samantha Sharpe,Lisa Wise,Erik Zmuda,Stephen J. Chanock,Tanja Davidsen,John A. Demchok,Greg Eley,Ina Felau,Brad Ozenberger,Margi Sheth,Heidi J. Sofia,Louis M. Staudt,Roy Tarnuzzer,Zhining Wang,Liming Yang,Jiashan Zhang,Larsson Omberg,Adam A. Margolin,Benjamin J. Raphael,Fabio Vandin,Hsin-Ta Wu,Mark D.M. Leiserson,Stephen C. Benz,Charles J. Vaske,Houtan Noushmehr,Denise M. Wolf,Laura van 't Veer,Eric A. Collisson,Dimitris Anastassiou,Tai-Hsien Ou Yang,Nuria Lopez-Bigas,Abel Gonzalez-Perez,David Tamborero,Zheng Xia,Wei Li,Dong-Yeon Cho,Teresa M. Przytycka,Mark P. Hamilton,Sean E. McGuire,Sven Nelander,Patrik Johansson,Rebecka Jörnsten,Teresia Kling,Jose Miguel Sanchez,Kenna R. Mills Shaw +337 more
TL;DR: The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels as mentioned in this paper.
Journal ArticleDOI
X-ray structure of Candida antarctica lipase A shows a novel lid structure and a likely mode of interfacial activation.
Daniel J. Ericsson,Alex Kasrayan,Patrik Johansson,Terese Bergfors,Anders G. Sandström,Jan-Erling Bäckvall,Sherry L. Mowbray +6 more
TL;DR: The X-ray structure of lipase A from Candida antarctica is reported, solved by single isomorphous replacement with anomalous scattering, and refined to 2.2-A resolution, providing a basis for understanding the enzyme's preference for acyl moieties with long, straight tails, and for its highly promiscuous acceptance of widely different alcohol and amine moieties.
Journal ArticleDOI
Structural insight into allosteric modulation of protease-activated receptor 2
Robert K. Y. Cheng,Cédric Fiez-Vandal,Oliver Schlenker,Karl Edman,Birte Aggeler,Dean G. Brown,Giles A. Brown,Robert M. Cooke,Christoph E. Dumelin,A.S. Dore,Stefan Geschwindner,Christoph Grebner,Nils-Olov Hermansson,Ali Jazayeri,Patrik Johansson,Louis Leong,Rudi Prihandoko,Mathieu Rappas,Holly H. Soutter,Arjan Snijder,Linda Sundström,Benjamin Tehan,Peter E. Thornton,Dawn M. Troast,Giselle R. Wiggin,Andrei Zhukov,Fiona H. Marshall,Niek Dekker +27 more
TL;DR: Crystal structures of PAR2 in complex with two distinct antagonists and a blocking antibody provide a basis for the development of selective PAR2 antagonists for a range of therapeutic uses.
Journal ArticleDOI
Crystal structures of a poplar xyloglucan endotransglycosylase reveal details of transglycosylation acceptor binding.
Patrik Johansson,Harry Brumer,Martin J. Baumann,Åsa M. Kallas,Hongbin Henriksson,Stuart E. Denman,Tuula T. Teeri,T. Alwyn Jones +7 more
TL;DR: The structure of XET in complex with a xyloglucan nonasaccharide, XLLG, reveals a very favorable acceptor binding site, which is a necessary but not sufficient prerequisite for transglycosylation.