Jan Hendrik Niess

TL;DR: A myeloid-derived mucosal DC in mice is identified, which populates the entire lamina propria of the small intestine, and CX3CR1-dependent processes, which control host interactions of specialized DCs with commensal and pathogenic bacteria, may regulate immunological tolerance and inflammation.

TL;DR: It is demonstrated that a specialized DC subset in Peyer's patches (PPs) mediates the rapid activation of pathogen specific T cells as well as localized T cell dependent defense against entero-invasive pathogens.

TL;DR: Understanding DC biology in the mucosal immune system may contribute to the unraveling of infection routes of intestinal pathogens and may aid in developing novel vaccines and therapeutic strategies for the treatment of infectious and inflammatory diseases.

TL;DR: Dendritic cells emerge as key regulators of the intestinal immune system with their ability to direct intestine-specific migration and control of T cells, leading to tolerance and immunity.

TL;DR: A major focus of mucosal immunology will be to understand how diverse dendritic cell subsets cooperate in regulating homeostasis and host defense in the different intestinal immune compartments, pivotal to understanding how the mucosal immune system makes the distinction between commensal microbiota, pathogens and self antigens.