Xiubin Gu

TL;DR: A myeloid-derived mucosal DC in mice is identified, which populates the entire lamina propria of the small intestine, and CX3CR1-dependent processes, which control host interactions of specialized DCs with commensal and pathogenic bacteria, may regulate immunological tolerance and inflammation.

TL;DR: It is demonstrated that a specialized DC subset in Peyer's patches (PPs) mediates the rapid activation of pathogen specific T cells as well as localized T cell dependent defense against entero-invasive pathogens.

TL;DR: In mice, HNF-1α was required for claudin-2 expression in the villus epithelium of the ileum and within the liver but not in the kidneys, indicating an organ-specific function of HNF -1α in the regulation of claudIn-2 gene expression.

TL;DR: It is demonstrated that Shigella flexneri has evolved the ability to regulate functional components of tight junctions after interaction at the apical and basolateral pole of model intestinal epithelia.

TL;DR: CX3CR1 mediates distinct functional responses in intestinal epithelial cells, which include the autocrine regulation of cell-survival signals and activation of immune modulators, indicating a role of CX3 CR1 in host defense mechanisms originating from the intestinal epithelium.