J
Jan M.C. Geuns
Researcher at Katholieke Universiteit Leuven
Publications - 92
Citations - 2647
Jan M.C. Geuns is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Steviol & Stevioside. The author has an hindex of 26, co-authored 92 publications receiving 2354 citations.
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Journal ArticleDOI
Steviol glycosides: chemical diversity, metabolism, and function.
Stijn Ceunen,Jan M.C. Geuns +1 more
TL;DR: A review of a group of highly sweet diterpene glycosides discovered in only a few plant species, most notably the Paraguayan shrub Stevia rebaudiana, to discuss the available knowledge on their in vivo biochemistry and metabolism and their relationship to the overall plant physiology.
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Steroid hormones and plant growth and development
TL;DR: The occurrence of steroid hormones in plants is briefly reviewed and their effects on plant growth, development and flowering are considered.
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Metabolism of stevioside by healthy subjects
TL;DR: Oral stevioside is not directly effective as a hypotensive or hypoglycemic agent in healthy subjects at the dose administered in this study.
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Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexes
Jan Van den Bossche,Pieter Bogaert,Jolanda van Hengel,Christopher J. Guérin,Geert Berx,Kiavash Movahedi,Rafael Van den Bergh,Anna Pereira-Fernandes,Jan M.C. Geuns,Hanspeter Pircher,Pierre Dorny,Johan Grooten,Patrick De Baetselier,Jo A. Van Ginderachter +13 more
TL;DR: The E-cadherin/catenin complex is identified as a discriminative, partly polyamine-regulated feature of IL-4/IL-13-exposed alternatively activated macrophages that contributes to homotypic and heterotypic cellular interactions.
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Pivotal Advance: Arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genes
Jan Van den Bossche,Wouter H. Lamers,Eleonore S. Koehler,Jan M.C. Geuns,Leena Alhonen,Anne Uimari,Sini Pirnes-Karhu,Eva Van Overmeire,Yannick Morias,Lea Brys,Lars Vereecke,Patrick De Baetselier,Jo A. Van Ginderachter +12 more
TL;DR: It is demonstrated for the first time that several, but not all, AAM markers depend on polyamines for their IL‐4‐induced gene and protein expression and that polyamine dependency of genes relies on the macrophage type.