S
Sini Pirnes-Karhu
Researcher at University of Helsinki
Publications - 11
Citations - 463
Sini Pirnes-Karhu is an academic researcher from University of Helsinki. The author has contributed to research in topics: Spermine & Spermidine. The author has an hindex of 6, co-authored 10 publications receiving 373 citations. Previous affiliations of Sini Pirnes-Karhu include University of Eastern Finland.
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Journal ArticleDOI
Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism
Joni Nikkanen,Saara Forsström,Liliya Euro,Ilse Paetau,Rebecca A. Kohnz,Liya Wang,Dmitri Chilov,Jenni Viinamäki,Anne Roivainen,Päivi Marjamäki,Heidi Liljenbäck,Sofia Ahola,Jana Buzkova,Mügen Terzioglu,Nahid Akhtar Khan,Sini Pirnes-Karhu,Anders Paetau,Tuula Lönnqvist,Antti Sajantila,Pirjo Isohanni,Henna Tyynismaa,Daniel K. Nomura,Brendan J. Battersby,Vidya Velagapudi,Christopher Carroll,Anu Suomalainen +25 more
TL;DR: It is reported that mtDNA replication disorders caused by TWINKLE mutations-mitochondrial myopathy (MM) and infantile onset spinocerebellar ataxia (IOSCA)-remodel cellular dNTP pools in mice are reported and targets for metabolic therapy are offered.
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Pivotal Advance: Arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genes
Jan Van den Bossche,Wouter H. Lamers,Eleonore S. Koehler,Jan M.C. Geuns,Leena Alhonen,Anne Uimari,Sini Pirnes-Karhu,Eva Van Overmeire,Yannick Morias,Lea Brys,Lars Vereecke,Patrick De Baetselier,Jo A. Van Ginderachter +12 more
TL;DR: It is demonstrated for the first time that several, but not all, AAM markers depend on polyamines for their IL‐4‐induced gene and protein expression and that polyamine dependency of genes relies on the macrophage type.
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Adipose tissue NAD+-homeostasis, sirtuins and poly(ADP-ribose) polymerases -important players in mitochondrial metabolism and metabolic health
TL;DR: This review aims to summarize existing literature on the maintenance of intracellular NAD+ pools and the function of SIRTs and PARPs in adipose tissue during normal and obese conditions, with the purpose of comprehending their potential role in mitochondrial derangements and obesity associated metabolic complications.
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The activation of hepatic and muscle polyamine catabolism improves glucose homeostasis
Taina Koponen,Marc Cerrada-Gimenez,Eija Pirinen,Esa Hohtola,Jussi Paananen,Susanna Vuohelainen,Maija Tusa,Sini Pirnes-Karhu,Sami Heikkinen,Antti Virkamäki,Anne Uimari,Leena Alhonen,Markku Laakso +12 more
TL;DR: The results suggest that the tissue-specific targeting of activated polyamine catabolism may reveal new possibilities for the development of drugs boosting mitochondrial metabolism and eventually for treatment of obesity and type 2 diabetes.
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Lipopolysaccharide-induced anti-inflammatory acute phase response is enhanced in spermidine/spermine N1-acetyltransferase (SSAT) overexpressing mice.
TL;DR: The study suggests that SSAT overexpression obtained in SSAT mice enhances the anti-inflammatory actions in the acute phase of LPS-induced immune response.