K
Kiavash Movahedi
Researcher at Vrije Universiteit Brussel
Publications - 52
Citations - 6819
Kiavash Movahedi is an academic researcher from Vrije Universiteit Brussel. The author has contributed to research in topics: Tumor microenvironment & Macrophage. The author has an hindex of 23, co-authored 43 publications receiving 5328 citations.
Papers
More filters
Journal Article
Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T-CELL suppressive activity
Kiavash Movahedi,Martin Guiliams,Jan Van den Bossche,Rafael Van den Bergh,Conny Gysemans,Alain Beschin,Patrick De Baetselier,Jo A. Van Ginderachter +7 more
TL;DR: This work identified 2 distinct MDSC subfractions with clear morphologic, molecular, and functional differences, and refined tumor-induced MDSCs functions by uncovering mechanistically distinct M DSC subpopulations, potentially relevant for MDSc-targeted therapies.
Journal ArticleDOI
Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell–suppressive activity
Kiavash Movahedi,Martin Guilliams,Jan Van den Bossche,Rafael Van den Bergh,Conny Gysemans,Alain Beschin,Patrick De Baetselier,Jo A. Van Ginderachter +7 more
TL;DR: In this article, the authors identified two distinct MDSC subfractions with clear morphologic, molecular, and functional differences, i.e., low-density polymorphonuclear cells (PMN-MDSCs) and high-density neutrophils.
Journal ArticleDOI
Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes
Kiavash Movahedi,Damya Laoui,Conny Gysemans,Martijn Baeten,Geert Stangé,Jan Van den Bossche,Matthias Mack,Daniel Pipeleers,Peter In't Veld,Patrick De Baetselier,Jo A. Van Ginderachter +10 more
TL;DR: The data help to unravel the complexities of the tumor-infiltrating myeloid cell compartment and provide a rationale for targeting specialized TAM subsets, thereby optimally "re-educating" the TAM compartment.
Journal ArticleDOI
A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment.
Hannah Van Hove,Liesbet Martens,Isabelle Scheyltjens,Karen De Vlaminck,Ana Rita Pombo Antunes,Sofie De Prijck,Niels Vandamme,Sebastiaan De Schepper,Gert Van Isterdael,Charlotte L. Scott,Charlotte L. Scott,Jeroen Aerts,Geert Berx,Guy E. Boeckxstaens,Roosmarijn E. Vandenbroucke,Lars Vereecke,Diederik Moechars,Martin Guilliams,Jo A. Van Ginderachter,Yvan Saeys,Kiavash Movahedi +20 more
TL;DR: The results provide a framework for understanding host–macrophage interactions in both the healthy and diseased brain and identify IRF8 as a master regulator that drives the maturation and diversity of brain macrophages.
Journal ArticleDOI
Classical and alternative activation of mononuclear phagocytes: picking the best of both worlds for tumor promotion.
Jo A. Van Ginderachter,Kiavash Movahedi,Gholamreza Hassanzadeh Ghassabeh,Sofie Meerschaut,Alain Beschin,Geert Raes,Patrick De Baetselier +6 more
TL;DR: This review focuses on the mechanisms behind monocyte/macrophage-mediated tumor promotion and interprets the available data within the M1/M2 conceptual frame.