Lea Brys

TL;DR: In this paper, the p50 subunit of NF-κB was identified as a key regulator of M2-driven inflammatory reactions in vitro and in vivo, and p50-deficient mice showed exacerbated M1-driven inflammation and defective capacity to mount allergy and helminth-driven M2polarized inflammatory reactions.

TL;DR: It is demonstrated that expression of the two members of the mouse macrophage galactose‐type C‐type lectin gene family (mMGL1 and mMGL2) is induced in diverse populations of aaMF, including peritoneal macrophages elicited during infection with the protozoan Trypanosoma Brucei brucei or the Helminth Taenia crassiceps and alveolar macrophAGE elicited in a mouse model of allergic

TL;DR: Results suggest that the 42-kDa CCF-1 protein of E. foetida coelomic fluid likely plays a role in the protection of earthworms against microbes.

TL;DR: The data uncover the multifaceted and opposing roles of M-CS FR and GM-CSFR signaling in governing the phenotype of macrophage subsets in tumors, and provide new insight into the mechanism of action underlying M- CSFR blockade.

TL;DR: In this article, comparative gene expression profiling of M1 and M2 cells, elicited in murine models of parasitic infections and cancer, yielded a common signature for in vivo-induced M2 populations independent of disease model, mouse strain, and organ source of cells.