J
Jan Zedenius
Researcher at Karolinska University Hospital
Publications - 143
Citations - 7339
Jan Zedenius is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Thyroid carcinoma & Thyroid. The author has an hindex of 40, co-authored 132 publications receiving 6668 citations. Previous affiliations of Jan Zedenius include Sophiahemmet Hospital & Queen's University.
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Journal ArticleDOI
The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis.
Charis Eng,Charis Eng,David Clayton,I Schuffenecker,Gilbert M. Lenoir,Gilbert J. Cote,Robert F. Gagel,Hans Kristian Ploos van Amstel,Cornelis J.M. Lips,Isamu Nishisho,Shin ichiro Takai,Deborah J. Marsh,Deborah J. Marsh,Bruce G. Robinson,Karin Frank-Raue,Friedhelm Raue,Feiyu Xue,Walter W. Noll,Cristina Romei,Furio Pacini,Monika Fink,Bruno Niederle,Jan Zedenius,Magnus Nordenskjöld,Paul Komminoth,Geoffrey N. Hendy,Hossein Gharib,Stephen N. Thibodeau,André Lacroix,Andrea Frilling,Bruce A.J. Ponder,Bruce A.J. Ponder,Lois M. Mulligan +32 more
TL;DR: It is suggested that genotype-phenotype correlations do exist and, if made reliably absolute, could prove useful in the future in clinical management with respect to screening, surveillance, and prophylaxis, as well as provide insight into the genetic effects of particular mutations.
Journal ArticleDOI
Clinically significant prognostic factors for differentiated thyroid carcinoma: a population-based, nested case-control study.
TL;DR: The objective of the current study was to identify those factors that predict long‐term unfavorable prognosis and to evaluate the predictive accuracy of the TNM staging system.
Journal Article
Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors
Patricia L. M. Dahia,Deborah J. Marsh,Zimu Zheng,Jan Zedenius,Paul Komminoth,Tony Frisk,Göran Wallin,Ramon Parsons,Michel Longy,Catharina Larsson,Charis Eng,Charis Eng +11 more
TL;DR: It is concluded that a subset of thyroid tumors have somatic deletions of the PTEN gene, predominantly the benign forms, and that small intragenic mutations of PTEN are infrequent in thyroid tumors.
Journal ArticleDOI
Genotype-phenotype correlation in multiple endocrine neoplasia type 2: report of the International RET Mutation Consortium.
Lois M. Mulligan,Deborah J. Marsh,B. G. Robinson,I. Schuffenecker,Jan Zedenius,C. J.M. Lips,Robert F. Gagel,S. I. Takai,W. W. Noll,M. Fink,Friedhelm Raue,André Lacroix,S. N. Thibodeau,A. Frilling,Bruce A.J. Ponder,Charis Eng +15 more
TL;DR: The International RET Mutation Consortium was first convened as part of the Fifth International Workshop on Multiple Endocrine Neoplasia, Stockholm, Sweden, in an attempt to analyse the relationship of RET mutation and disease phenotype in the autosomal dominantly inherited multiple endocrine neoplasia type 2 (MEN 2) syndromes.
Journal ArticleDOI
Characterization of the mutational landscape of anaplastic thyroid cancer via whole exome sequencing
John W. Kunstman,C. Christofer Juhlin,Gerald Goh,Taylor C. Brown,Adam Stenman,James M. Healy,Jill C. Rubinstein,Murim Choi,Nimrod B Kiss,Carol Nelson-Williams,Shrikant Mane,David L. Rimm,Manju L. Prasad,Anders Höög,Jan Zedenius,Catharina Larsson,Reju Korah,Richard P. Lifton,Tobias Carling +18 more
TL;DR: This first comprehensive exome-wide analysis of the mutational landscape of ATC identifies novel genes potentially associated with ATC tumorigenesis, some of which may be targets for future therapeutic intervention.