J
Jana Korduláková
Researcher at Comenius University in Bratislava
Publications - 45
Citations - 2999
Jana Korduláková is an academic researcher from Comenius University in Bratislava. The author has contributed to research in topics: Mycobacterium tuberculosis & Mycobacterium smegmatis. The author has an hindex of 24, co-authored 45 publications receiving 2542 citations. Previous affiliations of Jana Korduláková include Pasteur Institute & University of Cologne.
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Journal ArticleDOI
Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis
Vadim Makarov,Giulia Manina,Katarína Mikušová,Ute Möllmann,O. B. Ryabova,Brigitte Saint-Joanis,Neeraj Dhar,Maria Rosalia Pasca,Silvia Buroni,Anna Paola Lucarelli,Anna Milano,Edda De Rossi,Martina Belanova,Adela Bobovská,Petronela Dianišková,Jana Korduláková,Claudia Sala,Elizabeth Fullam,Patricia Schneider,John D. McKinney,Priscille Brodin,Thierry Christophe,Simon J. Waddell,Philip D. Butcher,Jakob Albrethsen,Ida Rosenkrands,Roland Brosch,Vrinda Nandi,Sowmya Bharath,Sheshagiri Gaonkar,Radha Shandil,V. Balasubramanian,Tanjore S. Balganesh,Sandeep Tyagi,Jacques H. Grosset,Giovanna Riccardi,Stewart T. Cole +36 more
TL;DR: The synthesis and characterization of 1,3-benzothiazin-4-ones (BTZs), a new class of antimycobacterial agents that kill Mycobacterium tuberculosis in vitro, ex vivo, and in mouse models of TB are described.
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Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane
Anna E. Grzegorzewicz,Ha Pham,Vijay A. K.B. Gundi,Michael S. Scherman,Elton J. North,Tamara Hess,Victoria Jones,Veronica Gruppo,Sarah E. M. Born,Jana Korduláková,Sivagami Sundaram Chavadi,Christophe Morisseau,Anne J. Lenaerts,Richard E. Lee,Michael R. McNeil,Mary Jackson +15 more
TL;DR: Experiments revealed that the prototype inhibitor targets the inner membrane transporter, MmpL3, and support the involvement of this transporter in the translocation of trehalose monomycolate across the plasma membrane.
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Impact of Mycobacterium ulcerans Biofilm on Transmissibility to Ecological Niches and Buruli Ulcer Pathogenesis
Laurent Marsollier,Laurent Marsollier,Laurent Marsollier,Priscille Brodin,Mary Jackson,Jana Korduláková,Petra Tafelmeyer,Etienne Carbonnelle,Jacques Aubry,Jacques Aubry,Geneviève Milon,Pierre Legras,Jean-Paul Saint André,Céline Leroy,Jane Cottin,Marie Laure Joly Guillou,Gilles Reysset,Stewart T. Cole +17 more
TL;DR: The results of this study support a model whereby biofilm changes confer selective advantages to M. ulcerans in colonizing various ecological niches successfully, with repercussions for Buruli ulcer pathogenesis.
Journal ArticleDOI
Definition of the first mannosylation step in phosphatidylinositol mannoside synthesis. PimA is essential for growth of mycobacteria.
Jana Korduláková,Jana Korduláková,Martine Gilleron,Katarína Mikušová,Germain Puzo,Patrick J. Brennan,Brigitte Gicquel,Mary Jackson +7 more
TL;DR: It is demonstrated here that the pimA mutant is unable to grow at the higher temperature at which the rescue plasmid is lost, providing the first direct evidence of the essentiality of phosphatidylinositol mannosides for the growth of mycobacteria.
Journal ArticleDOI
Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria
Marcelo E. Guerin,Jana Korduláková,Jana Korduláková,Francis Schaeffer,Zuzana Svetlíková,Alejandro Buschiazzo,David Giganti,Brigitte Gicquel,Katarína Mikušová,Mary Jackson,Pedro M. Alzari +10 more
TL;DR: A novel mode of phosphatidylinositol recognition is revealed and this association leads to enzyme activation, providing a template for the development of potential antimycobacterial compounds.