J
Jana L. Jacobs
Researcher at University of Pittsburgh
Publications - 41
Citations - 1035
Jana L. Jacobs is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Medicine & Antibody. The author has an hindex of 13, co-authored 27 publications receiving 527 citations. Previous affiliations of Jana L. Jacobs include University of Michigan.
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Journal ArticleDOI
Mechanisms of MAVS regulation at the mitochondrial membrane.
Jana L. Jacobs,Carolyn B. Coyne +1 more
TL;DR: This review focuses on the MAVS regulome and review the cellular factors that regulate MAVS by protein-protein interactions, alterations in mitochondrial dynamics, and/or post-translational modifications.
Journal ArticleDOI
The emerging plasticity of SARS-CoV-2.
Journal ArticleDOI
Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study.
Matthew K Hensley,William Bain,William Bain,Jana L. Jacobs,Sham Nambulli,Urvi M. Parikh,Anthony R. Cillo,Brittany Staines,Amy Heaps,Michele D. Sobolewski,Linda J. Rennick,Bernard J.C. Macatangay,Cynthia Klamar-Blain,Georgios D Kitsios,Barbara Methé,Ashwin Somasundaram,Tullia C. Bruno,Carly Cardello,Feng Shan,Creg J. Workman,Prabir Ray,Anuradha Ray,Janet S. Lee,Rahil Sethi,William E. Schwarzmann,Mark S. Ladinsky,Pamela J. Bjorkman,Dario A. A. Vignali,W. Paul Duprex,Mounzer Agha,John W. Mellors,Kevin D. McCormick,Alison Morris,Ghady Haidar +33 more
TL;DR: In this article, a chimeric antigen receptor-modified T-cell therapy recipient developed severe coronavirus disease 2019, intractable RNAemia, and viral replication lasting >2 months.
Journal ArticleDOI
Persistent HIV-infected cells in cerebrospinal fluid are associated with poorer neurocognitive performance.
Serena Spudich,Kevin Robertson,Ronald J. Bosch,Rajesh T. Gandhi,Joshua C. Cyktor,Hanna Mar,Bernard J.C. Macatangay,Christina M. Lalama,Charles R. Rinaldo,Ann C. Collier,Catherine Godfrey,Joseph J. Eron,Deborah McMahon,Jana L. Jacobs,Dianna Koontz,Evelyn Hogg,Alyssa Vecchio,John W. Mellors +17 more
TL;DR: HIV-infected cells persist in CSF in almost half of individuals on long-term ART, and their detection is associated with poorer neurocognitive performance, and the impact of this finding is supported by the National Institutes of Health and NIMH.
Journal ArticleDOI
SARS-CoV-2 Viremia is Associated with COVID-19 Severity and Predicts Clinical Outcomes.
Jana L. Jacobs,William Bain,Asma Naqvi,Brittany Staines,Priscila M. S. Castanha,Haopu Yang,Haopu Yang,Valerie F. Boltz,Simon M. Barratt-Boyes,Ernesto T. A. Marques,Stephanie L. Mitchell,Barbara Methé,Tolani F. Olonisakin,Ghady Haidar,Thomas W. Burke,Elizabeth Petzold,Thomas N. Denny,Christopher W. Woods,Christopher W. Woods,Bryan J. McVerry,Janet S. Lee,Simon C. Watkins,Claudette M. St. Croix,Alison Morris,Mary F. Kearney,Mark S. Ladinsky,Pamela J. Bjorkman,Georgios D Kitsios,John W. Mellors +28 more
TL;DR: In this article, SARS-CoV-2 vRNA was detected in plasma of 100%, 52.6%, and 11.1% of ICU, non-ICU, and outpatients respectively.