Thomas N. Denny

TL;DR: TF viruses are enriched for higher Env content, enhanced cell-free infectivity, improved dendritic cell interaction, and relative IFN-α resistance, which should be considered in the development and testing of AIDS vaccines.

TL;DR: It is demonstrated that increasing surface expression of HLA-C is associated with reduced viral load and reduced rate of progression to low CD4+ T cell counts in African and European Americans.

TL;DR: The first genome-wide screen for SNPs that associate with alternative splicing and gene expression in human primary cells, evaluating 93 autopsy-collected cortical brain tissue samples with no defined neuropsychiatric condition and 80 peripheral blood mononucleated cell samples collected from living healthy donors, suggests that splicing effects may be of more phenotypic significance than overall gene expression changes.

TL;DR: It is concluded that deficient production of IFN-alpha by pDC2 from HIV-infected patients results from both selective loss of these cells and their qualitative dysfunction, likely to be key contributors to HIV pathogenesis.

TL;DR: Novel linear Ig heavy- and light-chain gene expression cassettes were designed to express Ig V(H) and V(L) genes isolated from sorted single B cells as IgG1 antibody without a cloning step to constitute a highly efficient strategy for rapid expression of Ig genes for high-throughput screening and analysis without cloning.