V
Veronika Polakova
Researcher at Academy of Sciences of the Czech Republic
Publications - 25
Citations - 986
Veronika Polakova is an academic researcher from Academy of Sciences of the Czech Republic. The author has contributed to research in topics: DNA repair & Population. The author has an hindex of 18, co-authored 23 publications receiving 928 citations. Previous affiliations of Veronika Polakova include First Faculty of Medicine, Charles University in Prague & Charles University in Prague.
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Journal ArticleDOI
Association of DNA repair polymorphisms with DNA repair functional outcomes in healthy human subjects.
Pavel Vodicka,Rudolf Stetina,Veronika Polakova,Elena Tulupova,Alessio Naccarati,Ludmila Vodickova,Rajesh Kumar,Rajesh Kumar,Monika Hanova,Barbara Pardini,Barbara Pardini,Jana Slyskova,Ludovit Musak,Giuseppe De Palma,Pavel Soucek,Kari Hemminki,Kari Hemminki +16 more
TL;DR: XRCC1 Arg399Gln and hOGG1 Ser326Cys polymorphisms seem to exert the predominant modulating effect on irradiation-specific DNA repair capacity and the capacity to repair DNA oxidative damage, respectively.
Journal ArticleDOI
Mutations and polymorphisms in TP53 gene--an overview on the role in colorectal cancer.
Alessio Naccarati,Veronika Polakova,Veronika Polakova,Barbara Pardini,Ludmila Vodickova,Ludmila Vodickova,Kari Hemminki,Rajesh Kumar,Pavel Vodicka,Pavel Vodicka +9 more
TL;DR: The inherited genetics of TP53 pathway components could be utilised to further define patient populations in their abilities to induce p53 activity in response to either DNA damaging or p53-targeted therapies.
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DNA repair genetic polymorphisms and risk of colorectal cancer in the Czech Republic.
Barbara Pardini,Alessio Naccarati,Jan Novotny,Zdenek Smerhovsky,Ludmila Vodickova,Veronika Polakova,Monika Hanova,Jana Slyskova,Elena Tulupova,Rajesh Kumar,M. Bortlik,Roberto Barale,Kari Hemminki,Pavel Vodicka +13 more
TL;DR: Considering the subtle effect of the DNA repair polymorphisms on the risk of colorectal cancer, exploration of gene-gene and gene-environmental interactions with a large sample size with sufficient statistical power are recommended.
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Polymorphisms in miRNA-binding sites of nucleotide excision repair genes and colorectal cancer risk.
Alessio Naccarati,Barbara Pardini,Landi Stefano,Debora Landi,Jana Slyskova,Jan Novotny,Miroslav Levy,Veronika Polakova,Ludmila Lipska,Pavel Vodicka +9 more
TL;DR: Variation in miRNA target binding sites in the 3'untranslated region of NER genes may be important for modulating colorectal cancer risk, with a different relevance according to tumor location.
Journal ArticleDOI
Genotype and haplotype analysis of cell cycle genes in sporadic colorectal cancer in the Czech Republic
Veronika Polakova,Veronika Polakova,Barbara Pardini,Alessio Naccarati,Stefano Landi,Jana Slyskova,Jan Novotny,Ludmila Vodickova,Justo Lorenzo Bermejo,Monika Hanova,Zdenek Smerhovsky,Elena Tulupova,Rajesh Kumar,Kari Hemminki,Pavel Vodicka +14 more
TL;DR: It is suggested that prevalent haplotypes within the TP53 gene may modulate CRC risks in the population and be observed with haplotypes of the CDKN1A and CDKN2A polymorphisms.