J
Janice M. Zabolotny
Researcher at Beth Israel Deaconess Medical Center
Publications - 20
Citations - 5635
Janice M. Zabolotny is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Insulin & Insulin receptor. The author has an hindex of 19, co-authored 20 publications receiving 5244 citations. Previous affiliations of Janice M. Zabolotny include Harvard University & Tufts University.
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Journal ArticleDOI
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
Qin Yang,Timothy E. Graham,Nimesh Mody,Frédéric Preitner,Odile D. Peroni,Janice M. Zabolotny,Ko Kotani,Loredana Quadro,Barbara B. Kahn +8 more
TL;DR: It is shown that expression of retinol binding protein-4 (RBP4) is elevated in adipose tissue of adipose-Glut4-/- mice and RBP4 is an adipocyte-derived ‘signal’ that may contribute to the pathogenesis of type 2 diabetes.
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Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice
Lori D. Klaman,Olivier Boss,Odile D. Peroni,Jason K. Kim,Jennifer L. Martino,Janice M. Zabolotny,Nadeem Moghal,Margaret Lubkin,Young-Bum Kim,Arlene H. Sharpe,Alain Stricker-Krongrad,Gerald I. Shulman,Benjamin G. Neel,Barbara B. Kahn +13 more
TL;DR: PTP-1B is identified as a major regulator of energy balance, insulin sensitivity, and body fat stores in vivo and is implicated in the regulation of insulin action and signal transduction pathways.
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PTP1B regulates leptin signal transduction in vivo.
Janice M. Zabolotny,Kendra K. Bence-Hanulec,Alain Stricker-Krongrad,Fawaz G. Haj,Yongping Wang,Yasuhiko Minokoshi,Young-Bum Kim,Joel K. Elmquist,Louis A. Tartaglia,Barbara B. Kahn,Benjamin G. Neel +10 more
TL;DR: It is shown that PTP1B regulates leptin signaling in vivo, likely by targeting Jak2, and may be a novel target to treat leptin resistance in obesity.
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Protein-tyrosine Phosphatase 1B Expression Is Induced by Inflammation in Vivo
Janice M. Zabolotny,Young-Bum Kim,Laura Welsh,Erin E. Kershaw,Benjamin G. Neel,Barbara B. Kahn +5 more
TL;DR: It is found that adipose tissue inflammation and the pro-inflammatory cytokine tumor necrosis factor α (TNFα) regulate PTP1B expression in vivo and that PTP 1B may be a target of anti-inflammatory therapies.
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Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action.
Janice M. Zabolotny,Fawaz G. Haj,Young-Bum Kim,Hyo-Jeong Kim,Gerald I. Shulman,Jason K. Kim,Benjamin G. Neel,Barbara B. Kahn +7 more
TL;DR: Lack of additive impairment of insulin signaling by PTP1B and LAR suggests that these PTPs have overlapping actions in causing insulin resistance in vivo.