Jared E. Duncan

TL;DR: It is demonstrated that predominant CD4+ T cell epitopes in persons with resolved HCV infection are preferentially located in the nonstructural proteins and are immunogenic in the context of multiple class II molecules.

TL;DR: In this article, the relationship between HIV-1-induced CD4+ T-cell depletion and hepatitis C virus (HCV)-specific CD8+ responses during viral persistence was determined by using an ELISpot (ELISpot) assay.

TL;DR: Insight is provided into the frequency and reproducibility of viral escape from CD8+ T cell responses in human HCV infection, and the combined influence of multiple forces shaping the sequence diversity of HCV and other highly variable pathogens are clarified.

TL;DR: It is indicated that HIV infection impairs the immune response to HCV—including in persons who have cleared HCV infection—and that HIV-1-infected individuals with spontaneous control of HCV remain at significant risk for a second episode ofHCV viremia.