N
Nicole Frahm
Researcher at Fred Hutchinson Cancer Research Center
Publications - 128
Citations - 11974
Nicole Frahm is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Epitope & HIV vaccine. The author has an hindex of 49, co-authored 125 publications receiving 10833 citations. Previous affiliations of Nicole Frahm include International AIDS Vaccine Initiative & Harvard University.
Papers
More filters
Journal ArticleDOI
Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial
Barton F. Haynes,Peter B. Gilbert,M. Juliana McElrath,Susan Zolla-Pazner,Georgia D. Tomaras,S. Munir Alam,David T. Evans,David C. Montefiori,Chitraporn Karnasuta,Ruengpueng Sutthent,Hua-Xin Liao,Anthony L. DeVico,George K. Lewis,Constance Williams,Abraham Pinter,Youyi Fong,Holly Janes,Allan C. deCamp,Yunda Huang,Mangala Rao,Erik Billings,Nicos Karasavvas,Merlin L. Robb,Viseth Ngauy,Mark de Souza,Robert Paris,Guido Ferrari,Robert T. Bailer,Kelly A. Soderberg,Charla Andrews,Phillip W. Berman,Nicole Frahm,Stephen C. De Rosa,Michael D. Alpert,Nicole L. Yates,Xiaoying Shen,Richard A. Koup,Punnee Pitisuttithum,Jaranit Kaewkungwal,Sorachai Nitayaphan,Supachai Rerks-Ngarm,Nelson L. Michael,Jerome H. Kim +42 more
TL;DR: V vaccines that are designed to induce higher levels of V1V2 antibodies and lower levels of Env-specific IgA antibodies than are induced by the RV144 vaccine may have improved efficacy against HIV-1 infection.
Journal ArticleDOI
HLA class I supertypes: a revised and updated classification
TL;DR: An updated classification of HLA-A and -B class I alleles into supertypes is provided, allowing others to utilize the classification approach going forward and to facilitate epitope identification and vaccine design studies, as well as investigations into disease association and correlates of immunity.
Journal ArticleDOI
The epigenetic landscape of T cell exhaustion
Debattama R. Sen,James Kaminski,R. Anthony Barnitz,Makoto Kurachi,Ulrike Gerdemann,Kathleen B. Yates,Hsiao-Wei Tsao,Jernej Godec,Martin W. LaFleur,Flavian D. Brown,Pierre Tonnerre,Raymond T. Chung,Damien C. Tully,Todd M. Allen,Nicole Frahm,Georg M. Lauer,E. John Wherry,Nir Yosef,Nir Yosef,W. Nicholas Haining,W. Nicholas Haining,W. Nicholas Haining +21 more
TL;DR: The accessible chromatin landscape in exhausted CD8+ T cells is defined and shown that it is distinct from functional memory CD8 + T cells, suggesting that exhausted T cells are a distinct lineage.
Journal ArticleDOI
Efficacy Trial of a DNA/rAd5 HIV-1 Preventive Vaccine
Scott M. Hammer,Magdalena E. Sobieszczyk,Holly Janes,Shelly Karuna,Mark J. Mulligan,Doug Grove,Beryl A. Koblin,Susan Buchbinder,Michael C. Keefer,Georgia D. Tomaras,Nicole Frahm,John Hural,Chuka Anude,Barney S. Graham,Mary E. Enama,Elizabeth Adams,Edwin DeJesus,Richard M. Novak,Ian Frank,Carter Bentley,Shelly Ramirez,Rong Fu,Richard A. Koup,John R. Mascola,Gary J. Nabel,David C. Montefiori,James G. Kublin,M. Juliana McElrath,Lawrence Corey,Peter B. Gilbert +29 more
TL;DR: The DNA/rAd5 vaccine regimen did not reduce either the rate of HIV-1 acquisition or the viral-load set point in the population studied and had an acceptable side-effect profile.
Journal ArticleDOI
Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology.
Amy W. Chung,Amy W. Chung,Manu P. Kumar,Kelly B. Arnold,Wen-Han Yu,Wen-Han Yu,Matthew K. Schoen,Laura J. Dunphy,Todd J. Suscovich,Nicole Frahm,Caitlyn Linde,Alison E. Mahan,Michelle Hoffner,Hendrik Streeck,Hendrik Streeck,Margaret E. Ackerman,M. Juliana McElrath,Hanneke Schuitemaker,Maria G. Pau,Lindsey R. Baden,Lindsey R. Baden,Jerome H. Kim,Jerome H. Kim,Nelson L. Michael,Dan H. Barouch,Dan H. Barouch,Douglas A. Lauffenburger,Galit Alter +27 more
TL;DR: Multi-dimensional relational comparisons of vaccine humoral fingerprints offer a unique approach for the evaluation and design of novel vaccines against pathogens for which correlates of protection remain elusive.