Marcus Daniels

TL;DR: These data provide the first systematic assessment of the overall neutralization sensitivities of a genetically and geographically diverse panel of circulating HIV-1 strains and can facilitate the systematic characterization of NAb responses elicited by candidate vaccine immunogens.

TL;DR: Breadth of neutralization was correlated with viral load, but not with CD4 count, history of past antiretroviral use, age, gender, race/ethnicity, or route of exposure.

TL;DR: It is shown that viral lineage effects rather than immune escape often explain apparent human leukocyte antigen (HLA)–mediated immune-escape mutations defined by older analysis methods.

TL;DR: This work investigates the diversification of HIV-1 env coding sequences in 81 very early B subtype infections previously shown to have resulted from transmission or expansion of single viruses or two closely related viruses, and highlights the role of CTL escape and hypermutation in shaping viral evolution during the establishment of new infections.

TL;DR: The relationship between HLA class I-associated polymorphisms and lower CD4+ cell count suggests that immune escape correlates with disease status, supporting an essential role of maintenance of effective CTL responses in immune control of HIV-1.