J
Julian Schulze zur Wiesch
Researcher at University of Hamburg
Publications - 221
Citations - 5852
Julian Schulze zur Wiesch is an academic researcher from University of Hamburg. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 31, co-authored 146 publications receiving 4192 citations. Previous affiliations of Julian Schulze zur Wiesch include Eppendorf (Germany) & Harvard University.
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Journal ArticleDOI
Expansion of HIV-specific T follicular helper cells in chronic HIV infection.
Madelene Lindqvist,Jan van Lunzen,Damien Z. Soghoian,Bjorn D. Kuhl,Srinika Ranasinghe,Gregory Kranias,Michael Flanders,Samuel Cutler,Naomi Yudanin,Matthias I. Muller,Isaiah Davis,Donna L. Farber,Philip Hartjen,Friedrich Haag,Galit Alter,Julian Schulze zur Wiesch,Hendrik Streeck +16 more
TL;DR: This study suggests that high levels of HIV viremia drive the expansion of TFH cells, which in turn leads to perturbations of B cell differentiation, resulting in dysregulated antibody production.
Journal ArticleDOI
Naturally occurring dominant resistance mutations to hepatitis c virus protease and polymerase inhibitors in treatment-naive patients
Thomas Kuntzen,Joerg Timm,Andrew Berical,Niall Lennon,Aaron M. Berlin,Sarah Young,Bongshin Lee,David Heckerman,Jonathan M. Carlson,Laura L. Reyor,Marianna Kleyman,Cory M. McMahon,Christopher E. Birch,Julian Schulze zur Wiesch,Timothy Ledlie,Michael Koehrsen,Chinnappa D. Kodira,Andrew Roberts,Georg M. Lauer,Hugo R. Rosen,Florian Bihl,Andreas Cerny,Ulrich Spengler,Zhimin Liu,Arthur Y. Kim,Yanming Xing,Arne Schneidewind,Margaret A. Madey,Jaquelyn Fleckenstein,Vicki M. Park,James E. Galagan,Chad Nusbaum,Bruce D. Walker,Bruce D. Walker,Gerond Lake-Bakaar,Eric S. Daar,Ira M. Jacobson,Edward D. Gomperts,Brian R. Edlin,Sharyne M. Donfield,Raymond T. Chung,Andrew H. Talal,Tony N. Marion,Bruce W. Birren,Matthew R. Henn,Todd M. Allen +45 more
TL;DR: Naturally occurring dominant STAT‐C resistance mutations are common in treatment‐naïve patients infected with HCV genotype 1, and their influence on treatment outcome should be characterized to evaluate possible benefits of drug resistance testing for individual tailoring of drug combinations when treatment options are limited due to previous nonresponse to peginterferon and ribavirin.
Journal ArticleDOI
CD8 Epitope Escape and Reversion in Acute HCV Infection
Joerg Timm,Georg M. Lauer,Daniel G. Kavanagh,Isabelle Sheridan,Arthur Y. Kim,Michaela Lucas,Thillagavathie Pillay,Kei Ouchi,Laura L. Reyor,Julian Schulze zur Wiesch,Rajesh T. Gandhi,Raymond T. Chung,Nina Bhardwaj,Paul Klenerman,Bruce D. Walker,Todd M. Allen +15 more
TL;DR: This article examined viral evolution in an immunodominant human histocompatibility leukocyte antigen (HLA)-B8-restricted NS3 epitope in subjects with acute hepatitis C virus (HCV) infection.
Journal ArticleDOI
High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8+ and CD4+ T Cells during Acute HCV Infection, Irrespective of Clinical Outcome
Victoria O. Kasprowicz,Julian Schulze zur Wiesch,Julian Schulze zur Wiesch,Julian Schulze zur Wiesch,Thomas Kuntzen,Brian E. Nolan,S. Longworth,Andrew Berical,Jenna Blum,Cory M. McMahon,Laura L. Reyor,Nahel Elias,Nahel Elias,William W. Kwok,Barbara G. McGovern,Gordon J. Freeman,Raymond T. Chung,Raymond T. Chung,Paul Klenerman,Lia Laura Lewis-Ximenez,Bruce D. Walker,Bruce D. Walker,Todd M. Allen,Arthur Y. Kim,Georg M. Lauer +24 more
TL;DR: The results suggest that an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection.
Journal ArticleDOI
Frequent neurocognitive deficits after recovery from mild COVID-19
Marcel S Woo,Jakob Heinrich Malsy,Jana Pöttgen,Susan Seddiq Zai,Friederike Ufer,Alexandros Hadjilaou,Stefan Schmiedel,Marylyn M. Addo,Christian Gerloff,Christoph Heesen,Julian Schulze zur Wiesch,Manuel A. Friese +11 more
TL;DR: It is demonstrated that sustained sub-clinical cognitive impairments might be a common complication after recovery from COVID-19 in young adults, regardless of clinical course that were unmasked by the diagnostic approach.