J
Jared L. Johnson
Researcher at Cornell University
Publications - 37
Citations - 1975
Jared L. Johnson is an academic researcher from Cornell University. The author has contributed to research in topics: Kinase & Biology. The author has an hindex of 15, co-authored 26 publications receiving 1282 citations. Previous affiliations of Jared L. Johnson include Harvard University & NewYork–Presbyterian Hospital.
Papers
More filters
Journal ArticleDOI
Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity
Fleur M. Ferguson,Zainab M. Doctor,Scott B. Ficarro,Scott B. Ficarro,Christopher M. Browne,Jarrod A. Marto,Jared L. Johnson,Tomer M. Yaron,Lewis C. Cantley,Nam Doo Kim,Taebo Sim,Taebo Sim,Matthew J. Berberich,Marian Kalocsay,Peter K. Sorger,Nathanael S. Gray +15 more
TL;DR: FMF-04-159-2 is developed and characterize, a tool compound that specifically targets CDK14 covalently and possesses a TAIRE kinase-biased selectivity profile, and represents an important step forward in understanding the cellular consequences of inhibitingCDK14 kinase activity.
Journal ArticleDOI
The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation
Ho Soo Lee,Zhonghui Lin,Zhonghui Lin,Sunyoung Chae,Young Suk Yoo,Byung-Gyu Kim,Youngsoo Lee,Jared L. Johnson,You-Sun Kim,Lewis C. Cantley,Chang-Woo Lee,Hongtao Yu,Hyeseong Cho +12 more
TL;DR: The results indicate that RSF1 regulates the dynamics of H2A histone modifications at mitotic centromeres and contributes to the maintenance of chromosome stability.
Journal ArticleDOI
Regulation of folate and methionine metabolism by multisite phosphorylation of human methylenetetrahydrofolate reductase.
Yuxiang Zheng,Shivan Ramsamooj,Qian Li,Jared L. Johnson,Tomer M. Yaron,Klaus Sharra,Lewis C. Cantley +6 more
TL;DR: The results suggest that MTH FR multisite phosphorylation coordinates with SAM binding to inhibit MTHFR activity in cells.
Journal ArticleDOI
Development of a CDK10/CycM in vitro Kinase Screening Assay and Identification of First Small-Molecule Inhibitors.
Thomas Robert,Jared L. Johnson,Roxane Guichaoua,Tomer M. Yaron,Stéphane Bach,Lewis C. Cantley,Pierre Colas +6 more
TL;DR: The identification of an optimized peptide phosphorylation substrate of CDK 10/CycM and the development of the first homogeneous, miniaturized CDK10/ CycM in vitro kinase assay are reported, and the ability of known CDK inhibitors are revealed.
Journal ArticleDOI
Mapping Post-Translational Modifications of de Novo Purine Biosynthetic Enzymes: Implications for Pathway Regulation.
Chunliang Liu,Giselle M. Knudsen,Anthony M. Pedley,Jingxuan He,Jared L. Johnson,Tomer M. Yaron,Lewis C. Cantley,Lewis C. Cantley,Stephen J. Benkovic +8 more
TL;DR: A role for post-translational modifications in pathway regulation and activation to meet intracellular purine demand is proposed.