Marian Kalocsay

TL;DR: An analysis of microsatellite instable (MSI) cell lines reveals the dysregulation of specific protein complexes associated with surveillance of mutation and translation and these and other protein complexes were associated with sensitivity to knockdown of several different genes.

TL;DR: By monitoring a single persistent DNA break, it is shown that, following DNA resection and RPA recruitment, Rad51 spreads chromosome-wide bidirectionally from the DSB but selectively only on the broken chromosome.

TL;DR: It is shown that peroxidase-catalyzed proximity labeling can be combined with isobaric tagging and mass spectrometry to enable quantitative, time-resolved measurement of GPCR agonist response in living cells.

TL;DR: An in vivo approach to identify proteins whose enrichment near cardiac CaV1.2 channels changes upon β-adrenergic stimulation finds the G protein Rad, which is phosphorylated by protein kinase A, thereby relieving channel inhibition by Rad and causing an increased Ca2+ current.

TL;DR: The RNA-processing factor Nudt21 is identified as a novel post-transcriptional regulator of cell fate change using transcription-factor-induced reprogramming as a screening assay and a direct, previously unappreciated link between alternative polyadenylation and chromatin signaling is established.