R
Rotem Sorek
Researcher at Weizmann Institute of Science
Publications - 159
Citations - 22742
Rotem Sorek is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 57, co-authored 144 publications receiving 17956 citations. Previous affiliations of Rotem Sorek include Compugen & Tel Aviv University.
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Journal ArticleDOI
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
Dan Dominissini,Sharon Moshitch-Moshkovitz,Schraga Schwartz,Schraga Schwartz,Mali Salmon-Divon,Lior Ungar,Sivan Osenberg,Sivan Osenberg,Karen Cesarkas,Jasmine Jacob-Hirsch,Ninette Amariglio,Martin Kupiec,Rotem Sorek,Gideon Rechavi,Gideon Rechavi +14 more
TL;DR: The findings suggest that RNA decoration by m6A has a fundamental role in regulation of gene expression, and a subset of stimulus-dependent, dynamically modulated sites is identified.
Journal ArticleDOI
Metagenomic and functional analysis of hindgut microbiota of a wood-feeding higher termite.
Falk Warnecke,Peter Luginbuhl,Natalia Ivanova,Majid Ghassemian,Toby Richardson,Toby Richardson,Justin T. Stege,Michelle H. Cayouette,Alice C. McHardy,Gordana Djordjevic,Nahla Aboushadi,Rotem Sorek,Susannah G. Tringe,Mircea Podar,Hector Garcia Martin,Victor Kunin,Daniel Dalevi,Julita Madejska,Edward Kirton,Darren Platt,Ernest Szeto,Asaf Salamov,Kerrie Barry,Natalia Mikhailova,Nikos C. Kyrpides,Eric G. Matson,Elizabeth A. Ottesen,Xinning Zhang,Myriam Hernandez,Catalina Patricia Morales Murillo,Luis G. Acosta,Isidore Rigoutsos,Giselle Tamayo,Brian D. Green,Cathy Chang,Edward M. Rubin,Eric J. Mathur,Eric J. Mathur,Dan E. Robertson,Philip Hugenholtz,Jared R. Leadbetter +40 more
TL;DR: In this article, a metagenomic analysis of the bacterial community resident in the hindgut paunch of a wood-feeding Nasutitermes species (which do not contain cellulose-fermenting protozoa) was performed to show the presence of a large, diverse set of bacterial genes for cellulose and xylan hydrolysis.
Journal ArticleDOI
CRISPR--a widespread system that provides acquired resistance against phages in bacteria and archaea.
TL;DR: The structure and function of this newly recognized antiviral mechanism, together with a group of associated proteins, confer resistance to phages, possibly by an RNA-interference-like mechanism.
Journal ArticleDOI
Systematic discovery of antiphage defense systems in the microbial pangenome
Shany Doron,Sarah Melamed,Gal Ofir,Azita Leavitt,Anna Lopatina,Mai Keren,Gil Amitai,Rotem Sorek +7 more
TL;DR: This study comprehensively identify and experimentally verify new defense systems based on their enrichment within defense islands in an attempt to systematically map the arsenal of defense tools that are at the disposal of microbes in their fight against phages.
Journal ArticleDOI
Widespread occurrence of antisense transcription in the human genome
Rodrigo Yelin,Dvir Dahary,Rotem Sorek,Erez Y. Levanon,Orly Goldstein,Avi Shoshan,Alex Diber,Sharon Biton,Yael Tamir,Rami Khosravi,Sergey Nemzer,Elhanan Pinner,Shira Walach,Jeanne Bernstein,Kinneret Savitsky,Galit Rotman +15 more
TL;DR: The extent of antisense transcription in the human genome is studied by analyzing the public databases of expressed sequences using a set of computational tools designed to identify sense-antisense transcriptional units on opposite DNA strands of the same genomic locus to indicate that antisense modulation of gene expression in human cells may be a common regulatory mechanism.