Radislav Sedlacek

TL;DR: The alternative Dicer isoform, whose phylogenetic origin demonstrates evolutionary plasticity of RNA-silencing pathways, is the main determinant of endogenous RNAi activity in the mouse female germline.

TL;DR: Results show that intact mitochondria with their mtDNA payload are transferred in the developing tumour, and provide functional evidence for an essential role of oxidative phosphorylation in cancer.

TL;DR: Troy is up-regulated in human colorectal cancer cell lines and in intestinal tumors in mice, and functions as a negative modulator of the Wnt pathway in LGR5-positive stem cells.

TL;DR: In this paper, a single-cell and spatial atlas of each choroid plexus (ChP) in the developing, adult, and aged mouse brain was constructed, where diverse cell types, subtypes, cell states, and expression programs in epithelial and mesenchymal cells across ages and ventricles.

TL;DR: In this article, a bispecific IgG-1-like molecule (CoV-X2) was developed on the basis of C121 and C135, two antibodies derived from donors who had recovered from COVID-193.