J
Jason K. Whitmire
Researcher at University of North Carolina at Chapel Hill
Publications - 78
Citations - 6583
Jason K. Whitmire is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 41, co-authored 74 publications receiving 5887 citations. Previous affiliations of Jason K. Whitmire include Oregon Health & Science University & Scripps Research Institute.
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Journal ArticleDOI
Humoral immunity due to long-lived plasma cells
TL;DR: A substantial fraction of plasma cells can survive and continue to secrete antibody for extended periods of time in the absence of any detectable memory B cells, demonstrating a new mechanism by which humoral immunity is maintained.
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Interferon-γ acts directly on CD8+ T cells to increase their abundance during virus infection
TL;DR: The stimulatory effect is abrogated in T cells lacking the IFNγ receptor, indicating that the cytokine acts directly upon CD8+ T cells to increase their abundance during acute viral infection.
Journal Article
4-1BB Ligand, a Member of the TNF Family, Is Important for the Generation of Antiviral CD8 T Cell Responses
TL;DR: It is indicated that T cells have distinct costimulatory requirements: optimal CD8 responses require 4-1BBL-dependent interactions, whereas CD4 responses are minimally affected by4-1BB costimulation, but require CD40-CD40L and B7- dependent interactions.
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Conserved T Cell Receptor Repertoire in Primary and Memory CD8 T Cell Responses to an Acute Viral Infection
David J. D. Sourdive,Kaja Murali-Krishna,John D. Altman,Allan J. Zajac,Jason K. Whitmire,Christophe Pannetier,Philippe Kourilsky,Brian D. Evavold,A Sette,Rafi Ahmed +9 more
TL;DR: The analysis showed that CD8 T cells from several Vβ families participated in the anti-LCMV response directed to the dominant cytotoxic T lymphocyte (CTL) epitope, but the bulk of this CTL response was due to three privileged T cell populations systematically expanding during LCMV infection.
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A Role for Perforin in Downregulating T-Cell Responses during Chronic Viral Infection
Mehrdad Matloubian,M. Suresh,Alison A. Glass,Marisa Galvan,Kit Chow,Jason K. Whitmire,Craig M. Walsh,William R. Clark,Rafi Ahmed +8 more
TL;DR: The results show that the perforin-mediated pathway is involved in downregulating T-cell responses during chronic viral infection and autoimmunity and that per forin and Fas act independently as negative regulators of activated T cells.