M
M. Suresh
Researcher at University of Wisconsin-Madison
Publications - 123
Citations - 9331
M. Suresh is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 37, co-authored 115 publications receiving 8625 citations. Previous affiliations of M. Suresh include University of Minnesota & Emory University.
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Journal ArticleDOI
Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection
Kaja Murali-Krishna,John D. Altman,M. Suresh,David J. D. Sourdive,Allan J. Zajac,Joseph D. Miller,Jill E. Slansky,Rafi Ahmed +7 more
TL;DR: Much of the CD8 T cell expansion seen during viral infection represents antigen-specific cells and warrants a revision of current thinking on the size of the antiviral response.
Journal ArticleDOI
Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function
Allan J. Zajac,Joseph N. Blattman,Kaja Murali-Krishna,David J. D. Sourdive,M. Suresh,John D. Altman,Rafi Ahmed +6 more
TL;DR: The persistence of activated virus-specific CD8 T cells without effector function reveals a novel mechanism for silencing antiviral immune responses and also offers new possibilities for enhancingCD8 T cell immunity in chronically infected hosts.
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In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses
Yasushi Itoh,Kyoko Shinya,Maki Kiso,Tokiko Watanabe,Yoshihiro Sakoda,Masato Hatta,Yukiko Muramoto,Daisuke Tamura,Yuko Sakai-Tagawa,Takeshi Noda,Saori Sakabe,Masaki Imai,Yasuko Hatta,Shinji Watanabe,Chengjun Li,Shinya Yamada,Ken Fujii,Shin Murakami,Hirotaka Imai,Satoshi Kakugawa,Mutsumi Ito,Ryo Takano,Kiyoko Iwatsuki-Horimoto,Masayuki Shimojima,Taisuke Horimoto,Hideo Goto,Kei Takahashi,Akiko Makino,Hirohito Ishigaki,Misako Nakayama,Masatoshi Okamatsu,Kazuo Takahashi,David Warshauer,Peter A. Shult,Reiko Saito,Hiroshi Suzuki,Yousuke Furuta,Makoto Yamashita,Keiko Mitamura,Kunio Nakano,Morio Nakamura,Rebecca A. Brockman-Schneider,Hiroshi Mitamura,Masahiko Yamazaki,Norio Sugaya,M. Suresh,Makoto Ozawa,Makoto Ozawa,Gabriele Neumann,James E. Gern,Hiroshi Kida,Kazumasa Ogasawara,Yoshihiro Kawaoka +52 more
TL;DR: It is shown that CA04 is sensitive to approved and experimental antiviral drugs, suggesting that these compounds could function as a first line of defence against the recently declared S-OIV pandemic.
Journal ArticleDOI
Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus.
Darwyn Kobasa,Ayato Takada,Kyoko Shinya,Kyoko Shinya,Masato Hatta,Peter Halfmann,Steven Theriault,Hiroshi Suzuki,Hidekazu Nishimura,Keiko Mitamura,Norio Sugaya,Taichi Usui,Takeomi Murata,Yasuko Maeda,Shinji Watanabe,M. Suresh,Takashi Suzuki,Yasuo Suzuki,Heinz Feldmann,Yoshihiro Kawaoka,Yoshihiro Kawaoka +20 more
TL;DR: It is demonstrated that the HA of the 1918 virus confers enhanced pathogenicity in mice to recent human viruses that are otherwise non-pathogenic in this host.
Journal ArticleDOI
A Role for Perforin in Downregulating T-Cell Responses during Chronic Viral Infection
Mehrdad Matloubian,M. Suresh,Alison A. Glass,Marisa Galvan,Kit Chow,Jason K. Whitmire,Craig M. Walsh,William R. Clark,Rafi Ahmed +8 more
TL;DR: The results show that the perforin-mediated pathway is involved in downregulating T-cell responses during chronic viral infection and autoimmunity and that per forin and Fas act independently as negative regulators of activated T cells.