J
Jean-Christophe Rain
Researcher at Pasteur Institute
Publications - 59
Citations - 5594
Jean-Christophe Rain is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Spliceosome & RNA splicing. The author has an hindex of 22, co-authored 53 publications receiving 5262 citations. Previous affiliations of Jean-Christophe Rain include Centre national de la recherche scientifique.
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Journal ArticleDOI
The protein-protein interaction map of Helicobacter pylori.
Jean-Christophe Rain,Luc Selig,Hilde De Reuse,Véronique Battaglia,Céline Reverdy,Stéphane Simon,Gerlinde Lenzen,Fabien Petel,Jérôme Wojcik,Vincent Schächter,Y. Chemama,Agnès Labigne,Pierre Legrain +12 more
TL;DR: A large-scale protein–protein interaction map of the human gastric pathogen Helicobacter pylori is built and the assignment of unannotated proteins to biological pathways is permitted.
Journal ArticleDOI
Functional and physical interaction between Bcl‐XL and a BH3‐like domain in Beclin‐1
M. Chiara Maiuri,Gaetane Le Toumelin,Alfredo Criollo,Alfredo Criollo,Alfredo Criollo,Jean-Christophe Rain,Fabien Gautier,Philippe Juin,Ezgi Tasdemir,Ezgi Tasdemir,Ezgi Tasdemir,Gérard Pierron,Kostoula Troulinaki,Nektarios Tavernarakis,John A. Hickman,Olivier Geneste,Guido Kroemer,Guido Kroemer,Guido Kroemer +18 more
TL;DR: A novel autophagy‐stimulatory function of BH3‐only proteins beyond their established role as apoptosis inducers is revealed and is revealed by competitively disrupting the interaction between Beclin‐1 and B cl‐2 or Bcl‐XL.
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Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens.
TL;DR: A new yeast genomic library is constructed and a highly selective two-hybrid procedure adapted for exhaustive screens of the yeast genome is developed, able to characterize new interactions between known splicing factors, identify new yeast splicing Factors, and reveal novel potential functional links between cellular pathways.
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Disrupted in Schizophrenia 1 Interactome : evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia
L. M. Camargo,L. M. Camargo,Vincent Collura,Jean-Christophe Rain,Kenji Mizuguchi,Henning Hermjakob,Samuel Kerrien,Timothy P. Bonnert,Paul J. Whiting,Nicholas J. Brandon,Nicholas J. Brandon +10 more
TL;DR: It is shown that dysbindin and DISC1 share common PPIs suggesting they may affect common biological processes and that the function of schizophrenia risk genes may converge.
Journal ArticleDOI
Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells
Frédéric Colland,Etienne Formstecher,Xavier Jacq,Céline Reverdy,Cecile Planquette,Susan Conrath,Virginie Trouplin,Julie Bianchi,Vasily N. Aushev,Jacques Camonis,Alessandra Calabrese,Catherine Borg-Capra,Wolfgang Sippl,Vincent Collura,Guillaume Boissy,Jean-Christophe Rain,Philippe Guedat,Remi Delansorne,Laurent Daviet +18 more
TL;DR: HBX 41,108 is reported, a small-molecule compound that inhibits USP7 deubiquitinating activity with an IC50 in the submicromolar range, providing a structural basis for the development of new anticancer drugs.