J
Jean da Silva Correia
Researcher at Scripps Research Institute
Publications - 20
Citations - 2859
Jean da Silva Correia is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Receptor & Innate immune system. The author has an hindex of 19, co-authored 20 publications receiving 2709 citations.
Papers
More filters
Journal ArticleDOI
Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2.
TL;DR: It is shown that LPS is cross-linked specifically to TLR4 and MD-2 only when co-expressed with CD14, and contention that L PS is in close proximity to the three known proteins of its membrane receptor complex is supported.
Journal ArticleDOI
MD-2 and TLR4 N-Linked Glycosylations Are Important for a Functional Lipopolysaccharide Receptor *
TL;DR: The double mutant of MD-2 failed to support LPS-induced activation of an interleukin-8 (IL-8) promoter-driven luciferase reporter to induce IL-8 secretion or to activate amino-terminal c-Jun kinase (JNK).
Journal ArticleDOI
IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition.
M. Germana Sanna,Jean da Silva Correia,Odile Ducrey,Jongdae Lee,Ken Nomoto,Nicolas Schrantz,Quinn Deveraux,Richard J. Ulevitch +7 more
TL;DR: The data suggest that XIAP's antiapoptotic activity is achieved by two separate mechanisms: one requiring TAK1-dependent JNK1 activation and the second involving caspase inhibition.
Journal ArticleDOI
A Synthetic TLR4 Antagonist Has Anti-Inflammatory Effects in Two Murine Models of Inflammatory Bowel Disease
Madeleine M. Fort,Afsaneh Mozaffarian,Axel G. Stöver,Jean da Silva Correia,Johnson David A,R. Thomas Crane,Richard J. Ulevitch,David H. Persing,Helle Bielefeldt-Ohmann,Peter Probst,Eric W. Jeffery,Steven P. Fling,Robert M. Hershberg +12 more
TL;DR: Treatment with CRX-526 inhibits the development of moderate-to-severe disease in two mouse models of colonic inflammation: the dextran sodium sulfate model and multidrug resistance gene 1a-deficient mice.
Journal ArticleDOI
An Inflammasome-Independent Role for Epithelial-Expressed Nlrp3 in Renal Ischemia-Reperfusion Injury
Alana A. Shigeoka,James L. Mueller,Amanpreet Kambo,John C. Mathison,Andrew J. King,Wesley F. Hall,Jean da Silva Correia,Richard J. Ulevitch,Hal M. Hoffman,Dianne B. McKay +9 more
TL;DR: It is concluded that Nlrp3 contributes to renal IRI by a direct effect on renal tubular epithelium and that this effect is independent of inflammasome-induced proinflammatory cytokine production.