Jean-Guy Fournier

TL;DR: Although all of the mice injected with homogenate from BSE-infected cattle brain exhibited neurological symptoms and neuronal death, more than 55 percent had no detectable PrPres, suggesting that a further unidentified agent may actually transmit BSE.

TL;DR: The data allow the correlation of the differential expression of pro and/or active forms of M MP-2 and MMP-9 with different stages of the degeneration-regeneration process: MMP -9 expression is related to the inflammatory response and probably to the activation of satellite cells, whereas Mmp-2 activation is concomitant with the regeneration of new myofibers.

TL;DR: It is shown that BSE can be transmitted from primate to primate by intravenous route in 25 months, and an iatrogenic transmission of vCJD to humans could be readily recognized pathologically, whether it occurs by the central or peripheral route.

TL;DR: This work confirms that the N-terminal extremity of PrPres is differentially sensitive to proteases and provides new tools which will be made available to facilitate progress in qualitative and quantitative studies of PrP.

TL;DR: The presence of PrPc in synaptic terminals should provide additional informations on its possible role in neuronal transmission and on the implication of synapses in the pathogenesis of spongiform encephalopathies.