Nicolas Kopp

TL;DR: The present data demonstrate the existence of six phenotypic variants of sCJD, and the physicochemical properties of PrPSc in conjunction with the PRNP codon 129 genotype largely determine this phenotypesic variability, and allow a molecular classification of the disease variants.

TL;DR: This study demonstrated two primary cleavage sites at residue 82 and residue 97 for type 1 and type 2 PrP(Sc), respectively, and numerous secondary cleavages distributed along the region spanning residues 74-102, where the site of the PK cleavage varies mostly as a function of the PrP genotype at codon 129.

TL;DR: It is shown that BSE can be transmitted from primate to primate by intravenous route in 25 months, and an iatrogenic transmission of vCJD to humans could be readily recognized pathologically, whether it occurs by the central or peripheral route.