J
Jean Maccario
Researcher at French Institute of Health and Medical Research
Publications - 38
Citations - 2136
Jean Maccario is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Asthma & Atopy. The author has an hindex of 24, co-authored 38 publications receiving 1999 citations. Previous affiliations of Jean Maccario include University of Paris-Sud & Georgetown University Medical Center.
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Journal ArticleDOI
Inhibition of microRNA-92a Prevents Endothelial Dysfunction and Atherosclerosis in Mice
Xavier Loyer,Stephane Potteaux,Anne-Clémence Vion,Coralie L. Guerin,Sheerazed Boulkroun,Pierre-Emmanuel Rautou,Bhama Ramkhelawon,Bruno Esposito,Marion Dalloz,Jean-Louis Paul,Pierre Julia,Jean Maccario,Chantal M. Boulanger,Ziad Mallat,Alain Tedgui +14 more
TL;DR: Upregulation of miR-92a by oxLDL in atheroprone areas promotes endothelial activation and the development of atherosclerotic lesions, and miR -92a antagomir seems as a new atheroprotective therapeutic strategy.
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Asthma severity is associated with body mass index and early menarche in women.
TL;DR: The hypothesis of hormonal factors involved in the severity of asthma, which was unrelated to sex, increased with BMI in women but not in men, and the association was stronger in women with early menarche than in women without earlyMenarche.
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In vivo and in vitro peripheral-type benzodiazepine receptor polymerization: functional significance in drug ligand and cholesterol binding.
Franck Delavoie,Hua Li,Matthew Hardwick,Jean-Claude Robert,Christoforos Giatzakis,Gabriel Péranzi,Zhi-Xing Yao,Jean Maccario,Jean-Jacques Lacapère,Vassilios Papadopoulos +9 more
TL;DR: Data indicate that reactive oxygen species induce in vivo and in vitro the formation of covalent PBR polymers and that PBR polymerization is a dynamic process modulating the function of this receptor in cholesterol transport and other cell-specific PBR-mediated functions.
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Structural and functional study of reconstituted peripheral benzodiazepine receptor.
Jean-Jacques Lacapère,Franck Delavoie,Franck Delavoie,Hua Li,Gabriel Péranzi,Jean Maccario,Vassilios Papadopoulos,Branislav Vidic +7 more
TL;DR: The data suggest that a PBR monomer is the minimal functional unit, binding drug ligands and cholesterol, as well as the ability to bind both the PBR drug ligand isoquinoline carboxamide PK 11195 and cholesterol with nanomolar affinities.
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Relationships of active and passive smoking to total IgE in adults of the Epidemiological Study of the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness, and Atopy (EGEA).
Marie-Pierre Oryszczyn,Isabella Annesi-Maesano,Denis Charpin,Evelyne Paty,Jean Maccario,Francine Kauffmann +5 more
TL;DR: Results show that an increase in total IgE in relation to active smoking may be evidenced even in asthmatic probands despite the healthy smoker effect, andceptible subjects, such as women who are first-degree relatives of asthmatics, may increase total IgEs in connection to passive smoking.