Jean-Pierre Gorvel

TL;DR: It is demonstrated that phospholipase A2-derived peptides may have the potential to counteract microbial infections and encourage further evaluations of their actions in vivo.

TL;DR: It is concluded that the WXXXE motif is essential for maintaining the tertiary structure of SifA, the functions of which require the interaction with the eukaryotic protein SKIP.

TL;DR: The results suggest that the TCR/CD3 may be associated with different kinase activities during its intracellular pathway following ligand triggering.

TL;DR: The synthetic 13-mer p115-W3 constitutes the first example of a short, PLA(2)-based linear synthetic peptide with the ability to reproduce this effect of a parent protein in vivo, and is in clear support of the proposed relevance of the C-terminal region 115-129 in all the membrane-damaging mechanisms exerted by myotoxin II, including the myotoxic mechanism.

TL;DR: Examination of the internalization of LPS and its interaction with antigen-presenting major histocompatibility complex (MHC) class II molecules in murine and human B-cell lines raises the possibility that B. abortus LPS may play a role in T-cell activation.