J
Jean-Pierre Gorvel
Researcher at Aix-Marseille University
Publications - 239
Citations - 16211
Jean-Pierre Gorvel is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Brucella & Endosome. The author has an hindex of 67, co-authored 231 publications receiving 15005 citations. Previous affiliations of Jean-Pierre Gorvel include Centre national de la recherche scientifique & Aberystwyth University.
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Journal ArticleDOI
Intracellular trafficking of Parachlamydia acanthamoebae.
TL;DR: P. acanthamoebae survives to destruction by human macrophages probably by controlling the vacuole biogenesis, and traffic through the endocytic pathway is analysed.
Journal ArticleDOI
Functional Specialty of CD40 and Dendritic Cell Surface Lectins for Exogenous Antigen Presentation to CD8(+) and CD4(+) T Cells.
Wenjie Yin,Laurent Gorvel,Sandra Zurawski,Dapeng Li,Ling Ni,Dorothée Duluc,Katherine Upchurch,Jong R. Kim,Chao Gu,Richard Ouedraogo,Zhiqing Wang,Yaming Xue,HyeMee Joo,Jean-Pierre Gorvel,Gerard Zurawski,Sangkon Oh +15 more
TL;DR: It is demonstrated that antigen targeting to CD40 can evoke potent antigen-specific CD8+ T cell responses in human CD40 transgenic mice, providing fundamental information for the rational design of vaccines against cancers and viral infections.
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Characterization of Brucella abortus lipopolysaccharide macrodomains as mega rafts.
Nicolas Lapaque,Frédérique Forquet,Chantal de Chastellier,Zohair Mishal,Gilles Jolly,Edgardo Moreno,Ignacio Moriyón,John E. Heuser,Hai‐Tao He,Jean-Pierre Gorvel +9 more
TL;DR: It is shown for the first time that LPS macrodomains act as detergent resistant membranes (DRMs), segregating several lipid‐raft components, LPS‐binding proteins and MHC‐II molecules.
Journal ArticleDOI
RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4
Seigo Terawaki,Voahirana Camosseto,Francesca Prete,Till Wenger,Alexia Papadopoulos,Christiane Rondeau,Alexis J. Combes,Christian Rodriguez Rodrigues,Thien-Phong Vu Manh,Mathieu Fallet,Luc English,Rodrigo Santamaría,Ana R. Soares,Tobias Weil,Hamida Hammad,Michel Desjardins,Jean-Pierre Gorvel,Manuel A. S. Santos,Evelina Gatti,Evelina Gatti,Philippe Pierre,Philippe Pierre +21 more
TL;DR: Interleukin-4 boosts the capacity of dendritic cells to present endogenous antigens on MHC II and to resist bacterial infection through a mechanism shown to be partially dependent on RUFY4 expression.
Journal ArticleDOI
Escherichia coli α-hemolysin counteracts the anti-virulence innate immune response triggered by the Rho GTPase activating toxin CNF1 during bacteremia.
Mamady Diabate,Patrick Munro,Elsa Garcia,Arnaud Jacquel,Gregory Michel,Sandrine Obba,Diogo Gonçalvès,Carmelo Luci,Sandrine Marchetti,Dieter Demon,Clara Degos,Yassina Bechah,Jean-Louis Mege,Mohamed Lamkanfi,Patrick Auberger,Jean-Pierre Gorvel,Lynda M. Stuart,Luce Landraud,Emmanuel Lemichez,Laurent Boyer +19 more
TL;DR: The first example of anti-virulence-triggered immunity counteracted by a pore-forming toxin during bacteremia is reported, revealing the central role of the IL-1β signaling axis and Gr1+ cells in controlling the Escherichia coli burden in the blood in response to the sensing of the Rho GTPase-activating toxin CNF1.