J
Jean Pierre Rosat
Researcher at Brigham and Women's Hospital
Publications - 7
Citations - 1704
Jean Pierre Rosat is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 7, co-authored 7 publications receiving 1681 citations. Previous affiliations of Jean Pierre Rosat include Harvard University.
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Journal ArticleDOI
Differential effects of cytolytic T cell subsets on intracellular infection
Steffen Stenger,Richard J. Mazzaccaro,Koichi Uyemura,Sungae Cho,Peter F. Barnes,Jean Pierre Rosat,Alessandro Sette,Michael B. Brenner,Steven A. Porcelli,Barry R. Bloom,Robert L. Modlin +10 more
TL;DR: The data indicate that two phenotypically distinct subsets of human cytolytic T lymphocytes use different mechanisms to kill infected cells and contribute in different ways to host defense against intracellular infection.
Journal ArticleDOI
CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection
D. Branch Moody,Timo Ulrichs,Timo Ulrichs,Walter Mühlecker,David C. Young,Sudagar S Gurcha,Ethan P. Grant,Jean Pierre Rosat,Michael B. Brenner,Catherine E. Costello,Gurdyal S. Besra,Steven A. Porcelli,Steven A. Porcelli +12 more
TL;DR: It is shown that the T-cell antigen receptor and the CD1c protein mediate recognition of an evolutionarily conserved family of isoprenoid glycolipids whose members include essential components of protein glycosylation and cell-wall synthesis pathways.
Journal Article
CD1c restricts responses of mycobacteria-specific T cells. Evidence for antigen presentation by a second member of the human CD1 family.
Evan M. Beckman,Agustín Melián,Samuel M. Behar,Peter A. Sieling,Delphi Chatterjee,Stephen T. Furlong,R Matsumoto,R Matsumoto,Jean Pierre Rosat,Robert L. Modlin,Steven A. Porcelli +10 more
TL;DR: The findings support the general hypothesis that the CD1 family comprises a third lineage of Ag-presenting molecules that presents a novel class of foreign and self Ags to MHC-unrestricted T cells.
Journal Article
CD1-Restricted Microbial Lipid Antigen-Specific Recognition Found in the CD8+ αβ T Cell Pool
Jean Pierre Rosat,Ethan P. Grant,Evan M. Beckman,Christopher C. Dascher,Peter A. Sieling,Daphney Frederique,Robert L. Modlin,Steven A. Porcelli,Stephen T. Furlong,Michael B. Brenner +9 more
TL;DR: Two human CD8+ TCR αβ+ T cell lines specific for Mycobacterium tuberculosis Ags presented in the context of CD1a or CD1c Ag-presenting molecules are reported, implying that previous assumptions about the role of CD8- T cells in microbial immunity may require revision.
Journal ArticleDOI
Molecular Recognition of Lipid Antigens by T Cell Receptors
Ethan P. Grant,Massimo Degano,Jean Pierre Rosat,Steffen Stenger,Robert L. Modlin,Ian A. Wilson,Steven A. Porcelli,Michael B. Brenner +7 more
TL;DR: It is demonstrated that α/β TCRs, when transferred into TCR-deficient recipient cells, confer specificity for both the foreign lipid antigen and CD1 isoform.