J
Jeanette Östling
Researcher at Karolinska Institutet
Publications - 2
Citations - 464
Jeanette Östling is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Cancer & Innate immune system. The author has an hindex of 2, co-authored 2 publications receiving 326 citations.
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Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis
Anna-Maria Georgoudaki,Kajsa E. Prokopec,Vanessa F. Boura,Eva Hellqvist,Silke Sohn,Jeanette Östling,Rony Dahan,Robert A. Harris,Mattias Rantalainen,Daniel Klevebring,Malin Sund,Suzanne Egyhazi Brage,Jonas Fuxe,Charlotte Rolny,Fubin Li,Fubin Li,Jeffrey V. Ravetch,Mikael C. I. Karlsson +17 more
TL;DR: It is found that the pattern recognition scavenger receptor MARCO defines a subtype of suppressive TAMs and is linked to clinical outcome, and it is demonstrated that immunotherapies using antibodies designed to modify myeloid cells of the TME represent a promising mode of cancer treatment.
Journal ArticleDOI
Guidance Molecule SEMA3A Restricts Tumor Growth by Differentially Regulating the Proliferation of Tumor-Associated Macrophages.
Majken Wallerius,Tatjana Wallmann,Margarita Bartish,Jeanette Östling,Artur Mezheyeuski,Nicholas P. Tobin,Emma Nygren,Pradeepa N. Pangigadde,Paola Pellegrini,Mario Leonardo Squadrito,Fredrik Pontén,Johan Hartman,Jonas Bergh,Angelo De Milito,Michele De Palma,Arne Östman,John Andersson,Charlotte Rolny +17 more
TL;DR: In human breast cancer specimens, it was found that immunohistochemical levels of SEMA3A correlated with the expression of genes characteristic of M1 macrophages, CD8(+) T cells, and NK cells, while inversely correlating with established characters of malignancy.